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5326-47-6

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5326-47-6 Usage

Synthesis

To the mixture of 2.89 g (18.2 mmol) sodium 2- aminobenzoate, 40 mL acetic acid and 2.31 g (9.1 mmol) molecular iodine, 5 mL (44.1 mmol, 30 wt %) aqueous hydrogen peroxide was added drop wise. The S3 reaction mixture was stirred at 50 °C for 3 h and poured into 400 mL water. The formed crystals were filtered and recrystallized from benzene to give 2-azido-5- iodobenzoic acid . IR (suspension in nujol, cm?1 ): 3500, 3387, 1670, 1612, 1580, 1541, 1419, 1377, 1319, 1290, 1163, 1125, 813, 688, 619.

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-5-iodobenzoic acid is used in wide range of medicals industrial applications as well as in human and animal nutrition products such as pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 5326-47-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,2 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5326-47:
(6*5)+(5*3)+(4*2)+(3*6)+(2*4)+(1*7)=86
86 % 10 = 6
So 5326-47-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H6INO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)/p-1

5326-47-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A19838)  2-Amino-5-iodobenzoic acid, 98%   

  • 5326-47-6

  • 5g

  • 323.0CNY

  • Detail
  • Alfa Aesar

  • (A19838)  2-Amino-5-iodobenzoic acid, 98%   

  • 5326-47-6

  • 25g

  • 1089.0CNY

  • Detail
  • Aldrich

  • (A59603)  2-Amino-5-iodobenzoicacid  97%

  • 5326-47-6

  • A59603-5G

  • 257.40CNY

  • Detail
  • Aldrich

  • (A59603)  2-Amino-5-iodobenzoicacid  97%

  • 5326-47-6

  • A59603-25G

  • 786.24CNY

  • Detail
  • Aldrich

  • (A59603)  2-Amino-5-iodobenzoicacid  97%

  • 5326-47-6

  • A59603-100G

  • 2,655.90CNY

  • Detail

5326-47-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-iodobenzoic acid

1.2 Other means of identification

Product number -
Other names Benzoic acid,2-amino-5-iodo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5326-47-6 SDS

5326-47-6Relevant articles and documents

New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation

Hekal, Mohamed H.,Abu El-Azm, Fatma S. M.

, p. 2391 - 2402 (2018)

Since the quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors, a new series of 6-iodo-2-undecylquinazolin-4(3H)-ones were prepared via reaction of 6-iodo-2-undecyl-4H-benzoxazin-4-one with nitrogen nucleophiles, namely, primary amines, 4-amino antipyrine, hydrazine hydrate, diamines, ethanol amine, and/or hydrazide derivatives and screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 14, 16, and 18 showed remarkable broad spectrum antitumor activity. All compounds were fully characterized by means of IR, MS, and 1H-NMR spectra.

Discovery of novel quinazolinones and their acyclic analogues as multi-kinase inhibitors: design, synthesis, SAR analysis and biological evaluation

El Sayed, Nehad A.,Eissa, Amal A.,El Masry, Ghada F.,Abdullah, Mohamed?M.,Arafa, Reem K.

, p. 111767 - 111786 (2016)

This work deals with the design and synthesis of some novel 6-iodo-2-(pyridin-3/4-yl)-3-substituted quinazolin-4-one derivatives 8a-l, 10a-h, 13-18 in addition to certain acyclic analogues thereof viz.9a-n and 12a-h. The molecular design strategy was based on structural analogy between the new compounds and reported quinazolines and their acyclic analogues. This design scheme led to the synthesis of 8 new intermediates and 58 new final quinazolinones. The target compounds were evaluated for their antitumor activity against a panel of nine cancer cell lines viz. breast cancer (MCF-7, MDAMB-231, MDAMB-435 and HS-578T), colon cancer (HT-29 and HCC-2998) and leukemia (CCRF-CEM, K-562 and HL-60). The quinazolinones 10a-h displayed exceptional antitumor activity and compounds 12a-h showed superior potency against MCF-7. These compounds were further subjected to in vivo study. Kinase inhibitory assay was also carried out to investigate the mechanism of action of the target compounds and they displayed the highest activity against ABL, ALK and c-RAF kinases. The 3-substituted quinazolinones 10a-h showed the highest kinase activity inhibitory potency against ABL, ALK and c-RAF with the most active compound in this study being the fluoro-3-pyridyl derivative 10a. These results are in compliance with the observed antitumor activity. Finally, a molecular modeling study was performed to interpret the potential molecular interactions of these chemotypes with the most responsive biomolecular target ABL.

Improved method for microwave-assisted synthesis of benzodiazepine-2,5-diones from isatoic anhydrides mediated by glacial acetic acid

De La Cruz, Armando,Vega-Acevedo, Carlos Alejandro,Rivero, Ignacio A.,Chávez, Daniel

, p. 1607 - 1611 (2018/06/29)

An improved and simpler method for the synthesis of benzodiazepin-2,5-diones and 7-iodobenzodiazepin-2,5-diones catalyzed by glacial acetic acid using isatoic anhydride and 6-iodoisatoic anhydride, respectively, as starting materials is reported. The target products were achieved in good yields (up to 71percent) using microwave irradiation as the activating mode of reaction in the presence of acetic acid instead of the traditional polar aprotic solvents as dimethylformamide (DMF), dimethyl sulfoxide (DMSO) or dimethylacetamide (DMAC). Moreover, relatively simple purification workup is required. The optimal temperature to obtain the benzodiazepin-2,5-dione derivatives was 130 °C, while the best irradiation time was 3 min. In addition, the methodology for the selective preparation of 6-iodoisatoic anhydride with an overall yield of 62percent is presented. Printed in Brazil-

Synthesis of 2,1-benzisoxazole-3(1H)-ones by base-mediated photochemical N-O bond-forming cyclization of 2-azidobenzoic acids

Dzhons, Daria Yu.,Budruev, Andrei V.

supporting information, p. 874 - 881 (2016/07/06)

The base-mediated photochemical cyclization of 2-azidobenzoic acids with the formation of 2,1-benzisoxazole-3(1H)-ones is reported. The optimization and scope of this cyclization reaction is discussed. It is shown that an essential step of the ring closure of 2-azidobenzoic acids is the formation and photolysis of 2-azidobenzoate anions.

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