5326-91-0Relevant articles and documents
Dichloromeldrum's acid (DiCMA): A practical and green amine dichloroacetylation reagent
Heard, David M.,Lennox, Alastair J.J.
supporting information, p. 3368 - 3372 (2021/05/06)
Dichloromeldrum's acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and, as the only byproducts are acetone and CO2, no column chromatography is required. Thus, this reagent is practical, efficient, and green for the dichloroacetylation of primary amines.
Platinum on carbon-catalyzed precise reduction control of trichloromethyl to Geminal-dichloromethyl groups
Imanishi, Takahiro,Fujiwara, Yuta,Sawama, Yoshinari,Monguchi, Yasunari,Sajiki, Hironao
, p. 771 - 776 (2012/06/30)
Geminal-dichloromethyl derivatives could be efficiently synthesized by the highly chemoselective platinum on carbon-catalyzed mono-dechlorination of trichloromethyl substrates in dimethylacetamide (DMA) as a specific solvent at 25 °C under a hydrogen atmosphere. Copyright