5326-94-3

Basic information

• Product Name: 2-bromo-N-(2-nitrophenyl)acetamide
• Synonyms: 2-Bromo-N-(2-nitrophenyl)acetamide;2-bromo-N-(2-nitrophenyl)acetamide
• CAS NO: 5326-94-3
• Molecular Formula: C₈H₇BrN₂O₃
• Molecular Weight: 259.0568
• Mol File: 5326-94-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 74 °C(Solv: ethanol (64-17-5))
• Boiling Point: 431.1 °C at 760 mmHg
• Flash Point: 214.5 °C
• Appearance: /
• Density: 1.755 g/cm³
• Vapor Pressure: 1.23E-07mmHg at 25°C
• Refractive Index: 1.665
• PKA: 11.24±0.70(Predicted)
• CAS DataBase Reference: 2-bromo-N-(2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(2-nitrophenyl)acetamide(5326-94-3)
• EPA Substance Registry System: 2-bromo-N-(2-nitrophenyl)acetamide(5326-94-3)

Safety Data

• Hazardous Substances Data: 5326-94-3(Hazardous Substances Data)

Usage

General Description

2-bromo-N-(2-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H7BrN2O3. It is a white to light yellow crystalline powder that is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various organic compounds. 2-bromo-N-(2-nitrophenyl)acetamide is a bromo substituted acetamide with a nitrophenyl group attached to the nitrogen atom. It is known for its antimicrobial and antibacterial properties and is utilized in the development of new drugs and pharmaceutical products. Additionally, it is also used as a reagent in organic synthesis and research laboratories for various chemical reactions and experiments.

InChI:InChI=1/C8H7BrN2O3/c9-5-8(12)10-6-3-1-2-4-7(6)11(13)14/h1-4H,5H2,(H,10,12)

Upstream product

• 88-74-4 2-nitro-aniline 
• 598-21-0 2-Bromoacetyl bromide 
• 22118-09-8 2-bromoacetyl chloride 

Downstream Products

• 705969-13-7 2-(1-(naphthalen-1-yl)-1H-imidazol-2-ylthio)-N-(2-nitrophenyl)acetamide 
• 705969-14-8 2-{{4-(1-naphthalenyl)-4H-1,2,4-triazol-3-yl}thio}-N-(2-nitrophenyl)acetamide 

Relevant articles and documents

Synthesis and anticoccidial activities of novel N-(2-Aminophenyl)-2- quinazolinone-acetamide hydrochloride

Eight novel N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride were synthesized and their structures were identified by 1H NMR, MS and IR spectra. Seven of the new compounds were chosen for anticoccidial activity test and the results showed that N-(2- aminophenyl)-2-(6-methyl-8-bromo quinazolinone) acetamide hydrochloride (3h) exhibited anticoccidial activity against Eimeria tenella in the chicken' diet with a dose of 18 mg/Kg.

Facile synthesis, antimicrobial evaluation and molecular docking studies of pyrazole-imidazole-triazole hybrids

A series of eighteen pyrazole-imidazole-triazole hybrid (2-(4-((2-(substituted-1H-pyrazol-1-yl)-4-phenyl-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-(substituted)phenylacetami- de) (6a-6r) are synthesized through click reaction between in situ gener

Synthesis and antidiabetic evaluation of benzimidazole-tethered 1,2,3-triazoles

Some novel benzimidazole-tethered 1,2,3-triazole derivatives (4a–r) were synthesized by a click reaction between 2-substituted 1-(prop-2-yn-1-yl)-1H-benzo[d]imidazole and in situ azide. The structures of the synthesized compounds were confirmed by spectroscopic studies (one- and two-dimensional nuclear magnetic resonance, Fourier transform infrared, and high-resolution mass spectra). The synthesized compounds were evaluated for their antidiabetic activity. Compounds 4a–r exhibited a good-to-moderate α-amylase and α-glucosidase inhibitory activity, with IC50 values ranging from 0.0410 to 0.0916 μmol/ml and 0.0146 to 0.0732 μmol/ml, respectively. Compounds 4e, 4g, and 4n were found to be most active. Furthermore, the binding conformation of the most active compounds was ascertained by docking studies.