5327-59-3 Usage
Chemical structure
A synthetic steroid compound derived from cortisol.
Anti-inflammatory properties
Reduces inflammation by inhibiting the production of inflammatory substances in the body.
Immunosuppressive properties
Suppresses the immune system, which can be beneficial in treating autoimmune conditions.
Medical uses
Treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, asthma, and dermatitis.
Mechanism of action
As a glucocorticoid, it works by inhibiting the production of inflammatory substances, reducing swelling, redness, and pain.
Administration
Often administered topically or as an injection.
Side effects
Potential for adrenal suppression and increased risk of infections.
Precautions
Should be used with caution due to its potential side effects.
Molecular weight
Approximately 402.53 g/mol.
Appearance
Typically a white or off-white crystalline powder.
Solubility
Soluble in organic solvents, such as ethanol and methanol, and slightly soluble in water.
Stability
Stable under normal temperature and pressure conditions, but should be stored in a cool, dry place and protected from light to maintain its potency.
Check Digit Verification of cas no
The CAS Registry Mumber 5327-59-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,2 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5327-59:
(6*5)+(5*3)+(4*2)+(3*7)+(2*5)+(1*9)=93
93 % 10 = 3
So 5327-59-3 is a valid CAS Registry Number.
5327-59-3Relevant articles and documents
The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1)
Pettit, George R.,Mendonca, Ricardo F.,Knight, John C.,Pettit, Robin K.
, p. 1922 - 1930 (2011)
The synthesis of bis-steroidal pyrazines derived from 3-oxo-11,21- dihydroxypregna-4,17(20)-diene (4) and glycosylation of a D-ring side chain with α-L-rhamnose have been summarized. Rearrangement of steroidal pyrazine 10 to 14 was found to occur with boron triflouride etherate. Glycosylation of pyrazine 10 using 2,3,4-tri-O-acetyl-α-L-rhamnose iodide led to 1,2-orthoester-α-L-rhamnose pyrazine 17b. By use of a persilylated α-L-rhamnose iodide as donor, formation of the orthoester was avoided. Bis-steroidal pyrazine 10 and rhamnosides 17b and 21c were found to significantly inhibit cancer cell growth in a murine and human cancer cell line panel. Pyrazine 9 inhibited growth of the nosocomial pathogen Enterococcus faecalis.
