53279-63-3

Upstream product

• 186581-53-3 diazomethane 
• 17540-45-3 4-pentafluorophenoxy-2,3,4,5,6-pentafluorocyclohexa-2,5-dienone 
• 1386398-06-6 4,5,6,7,8-pentafluoro-6-pentafluorophenoxy-1-oxaspiro[2.5]octa-4,7-diene 
• 71-43-2 benzene 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 2926-29-6 Langlois reagent 

Relevant academic research and scientific papers

Electrochemical O-trifluoromethylation of electron-deficient phenols

A simple and sustainable one-step strategy for the preparation of electron-deficient aryl trifluoromethyl ethers (ArOCF3) from the corresponding phenols by electrochemical synthesis is presented. Anodic oxidation of trifluoromethane sulfinate (Langlois reagent) leads to direct O-trifluoromethylation of phenol-derivatives bearing fluorine, chlorine, bromine and nitrile substituents under mild conditions in yields up to 75% and in gram-scale. This electrochemical protocol provides an economic and green synthesis for an otherwise inaccessible class of molecules without the need for expensive or toxic reagents, oxidants or metal catalysts.

Acid-catalyzed polyfluoroarylation of arenes with polyfluorinated mono- and tris(phenoxy)-1-oxaspiro[2.5]octa-4,7-dienes

4,5,6,7,8-Pentafluoro-6-pentafluorophenoxy-1-oxaspiro[2.5]octa-4,7-diene and 4,6,8-tri-fluoro-5,6,7-tris(pentafluorophenoxy)-1-oxaspiro[2.5]octa-4,7- diene react with electron-rich arenes in the presence of AlCl3 or H2SO4 to give polyfluorinated phenoxybiaryls.