53279-82-6

Usage

Uses

Used in Organic Synthesis:
3-Iodo-4-methoxybenzyl alcohol is used as a reagent in organic synthesis for its ability to participate in a wide range of chemical reactions, facilitating the creation of complex organic molecules.
Used in Pharmaceutical Preparation:
In the pharmaceutical industry, 3-Iodo-4-methoxybenzyl alcohol is used as a key intermediate in the synthesis of various drugs. Its unique structure allows it to be incorporated into medicinal compounds to enhance their therapeutic properties.
Used in Agrochemical Production:
3-Iodo-4-methoxybenzyl alcohol also finds application in the agrochemical sector, where it serves as a precursor in the development of pesticides and other agricultural chemicals, contributing to the effectiveness of these products.
Used in Medicinal Chemistry Research:
Due to its potential biological activities, 3-Iodo-4-methoxybenzyl alcohol is utilized in research settings to explore its interactions with biological systems, which may lead to the discovery of new pharmaceutical agents or insights into disease mechanisms.
Used as a Precursor for Organic Compounds Synthesis:
Owing to its functional group compatibility, 3-Iodo-4-methoxybenzyl alcohol is employed as a precursor in the synthesis of a variety of organic compounds, expanding its utility across different areas of chemistry.

InChI:InChI=1/C8H9IO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-4,10H,5H2,1H3

Upstream product

• 35387-93-0 3-iodo-4-methoxy-benzoic acid methyl ester 
• 2314-37-6 3-iodo-4-methoxybenzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 91-61-2 6-methyl-1,2,3,4 tetrahydroquinoline 
• 60032-63-5 4-hydroxy-3-iodo-benzaldehyde 
• 2314-37-6 3-iodo-4-methoxybenzaldehyde 
• 1155702-70-7 3-[5-(hydroxymethyl)-2-methoxybenzyl]benzonitrile 

Relevant academic research and scientific papers

Entry to 1,2,3,4-Tetrasubstituted Arenes through Addressing the " Meta Constraint" in the Palladium/Norbornene Catalysis

Arenes with four different contiguous substituents, i.e. 1,2,3,4-tetrasubstituted arenes, are commonly found in bioactive compounds, but they are nontrivial to access via conventional methods. Through addressing the "meta constraint" in the palladium/norbornene (Pd/NBE) cooperative catalysis, which is the difficulty of tolerating a sizable meta substituent in aryl halide substrates, here a modular and regioselective approach is realized for preparing 1,2,3,4-tetrasubstituted arenes. One key is the use of a C2-amide-substituted NBE, and a combined experimental and computational study reveals its role in promoting the NBE insertion and the ortho C-H metalation steps. The scope is broad: A variety of electrophiles and nucleophiles could be introduced to the ortho and ipso positions, respectively, with 1,4-disubstituted aryl halides, leading to diverse unsymmetrical contiguous tetrasubstituted arenes. Application of this approach has been demonstrated in streamlined syntheses of several bioactive compounds.

Pd-catalyzed atom-efficient cross-coupling of triarylbismuth reagents with protecting group-free iodophenylmethanols: Synthesis of biarylmethanols

An atom-efficient procedure for the synthesis of functionalized biarylmethanols via the Pd-catalyzed cross-coupling reactions of differently functionalized iodophenylmethanols and triarylbismuth reagents is described. This protecting group-free direct couplings of 2-, 3- or 4-iodophenylmethanols with triarylbismuth reagents afforded biarylmethanols in good to high yields.

Effect of water on the functionalization of substituted anisoles with iodine in the presence of F-TEDA-BF4 or hydrogen peroxide

Water was found to be a convenient reaction medium for functionalization of substituted anisoles using iodine in the presence of Selectfluor F-TEDA-BF 4 or hydrogen peroxide as mediators and oxidizers. Two types of functionalization were observ

Tetramethylammonium dichloroiodate: An efficient and environmentally friendly iodination reagent for iodination of aromatic compounds under mild and solvent-free conditions

Tetramethylammonium dichloroiodate (1, TMADCI) as a mild and efficient iodination reagent was prepared. Iodination of different aromatic compounds with this reagent takes place fast and with high yields under solvent-free conditions.

N-iodosaccharin - A new reagent for iodination of alkenes and activated aromatics

A mild and efficient iodination reagent, N-iodosaccharin was prepared. Iodination of activated aromatics and alkenes with the reagent takes place fast and under very mild conditions, without the aid of strong acids or heavy metals. The reagent does not affect oxidizable groups, such as hydroxyl or aldehyde.