532958-99-9Relevant academic research and scientific papers
Synthesis of 1′-C-fluoromethyl-ddC by selectfluor-induced glycosylation of exo-glycals
Molas, Pineda,Di?az, Yolanda,Matheu, M. Isabel,Castillo?n, Sergio
, p. 207 - 210 (2007/10/03)
1′-C-fluoromethyl-ddC has been synthesized from 4-pentene-1,2-diol which is easily obtained from glycidol. The key steps are the synthesis of an exo-glycal by a 5-exo iodo-cyclization of a 4-pentene-1,2-diol and elimination, and a fluoro-glycosylation using an exo-glycal as glycosyl donor.
