532959-00-5

Upstream product

• 532958-96-6 (S)-2-Iodomethyl-5-trityloxymethyl-tetrahydro-furan 
• 183020-35-1 (S)-1-Trityloxy-hex-5-en-2-ol 
• 532958-97-7 ((S)-5-Iodomethyl-tetrahydro-furan-2-yl)-methanol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 532958-98-8 (S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-iodomethyl-tetrahydro-furan 

Downstream Products

• 532959-03-8 N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-fluoromethyl-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-acetamide 

Relevant academic research and scientific papers

Synthesis of 1′-C-fluoromethyl-ddC by selectfluor-induced glycosylation of exo-glycals

1′-C-fluoromethyl-ddC has been synthesized from 4-pentene-1,2-diol which is easily obtained from glycidol. The key steps are the synthesis of an exo-glycal by a 5-exo iodo-cyclization of a 4-pentene-1,2-diol and elimination, and a fluoro-glycosylation using an exo-glycal as glycosyl donor.