532978-09-9

Basic information

• Product Name: C₁₆H₁₁ClFN₃OS₂
• CAS NO: 532978-09-9
• Molecular Weight: 379.866
• Mol File: 532978-09-9.mol

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₁ClFN₃OS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₁ClFN₃OS₂(532978-09-9)
• EPA Substance Registry System: C₁₆H₁₁ClFN₃OS₂(532978-09-9)

Safety Data

• Hazardous Substances Data: 532978-09-9(Hazardous Substances Data)

Upstream product

• 299936-22-4 5-((4-fluorobenzyl)thio)-1,3,4-thiadiazol-2-amine 
• 609-65-4 o-chlorobenzoyl chloride 

Relevant articles and documents

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

A series of substituted benzoylamino-2-[(4-benzyl)thio]-1,3,4-thiadiazoles has been discovered as potent Abl tyrosine kinase inhibitors. Molecular docking simulations on the Abl tyrosine kinase were conducted in order to rationalize the SAR of the synthesized inhibitors. The most active compound identified from the enzymatic screening (6a) showed interesting inhibitory activity on Imatinib-sensitive murine myeloid 3B clone and Bcr-Abl-independent Imatinib-resistant leukemia cells. Surprisingly, 6a was also proved to act as differentiating inducers in human promyelocytic leukemia cells (HL-60).