5330-73-4

Usage

Appearance

Yellow crystalline solid

Molecular weight

243.22 g/mol

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Application

Intermediate in the preparation of other organic compounds

Role

Reagent in chemical reactions

Structural feature

Presence of a nitro group

Structural feature

Presence of a pyridine ring

Utility

Useful for various applications in organic synthesis and medicinal chemistry

Potential

Further study and development in scientific and industrial fields

InChI:InChI=1/C13H11N2O3/c16-13(10-14-8-2-1-3-9-14)11-4-6-12(7-5-11)15(17)18/h1-9H,10H2/q+1

Upstream product

• 110-86-1 pyridine 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 88007-99-2 2-methyl-3-(4-nitrophenacyl)-1,4-naphthoquinone 
• 112777-19-2 C₁₅H₁₂N₂O₃S₂ 
• 1569317-73-2 12-(4-nitrobenzoyl)-5H-cyclohepta[1,2-b:3,4-b':5,6-b'']trinaphthalene-5,6,11,13,18,19(12H)-hexaone 
• 1234895-90-9 methyl 3-(p-nitrobenzoyl)indolizine-1-carboxylate 
• 110186-76-0 methyl 2-(4-nitrophenyl)-2-oxoethanedithioate 
• 1514926-50-1 diethyl 3-(4-nitrobenzoyl)indolizine-1,2-dicarboxylate 
• 943011-71-0 5-methyl-2-(4-nitrophenyl)pyridine 
• 1325717-48-3 C₂₂H₁₄N₄O₄ 

Relevant academic research and scientific papers

Cyclization of Active Methylene Isocyanides with α-Oxodithioesters Induced by Base: An Expedient Synthesis of 4-Methylthio/Ethoxycarbonyl-5-acylthiazoles

Cyclization of tosylmethyl isocyanide with α-oxodithioesters in the presence of KOH is reported for the synthesis of 4-methylthio-5-acylthiazoles. Similarly, ethyl isocyanoacetate underwent cyclization with α-oxodithioesters to form 4-ethoxycarbonyl-5-acy

Acid-Catalyzed Condensation of o-Phenylenediammines and o-Aminophenols with α-Oxodithioesters: A Divergent and Regio? selective Synthesis of 2-Methylthio-3-Aryl/Heteroarylquinoxalines and 2-Acylbenzoxazoles

o-Phenylenediammines and o-Aminophenols were reacted with α-oxodithioesters in a highly regioselective fashion to give 2-methylthio-3-Aryl/heteroarylquinoxalines and 2-Acylbenzoxazoles in 55-94percent and 45-86percent, respectively, in the presence of p-T

Kr?hnke pyridines: Rapid and facile access to Mcl-1 inhibitors

The tumorigenic activity of upregulated Mcl-1 is manifested by binding the BH3 α-helical death domains of opposing Bcl-2 family members, neutralizing them and preventing apoptosis. Accordingly, the development of Mcl-1 inhibitors largely focuses on synthe

Facile synthesis of cyclometalated ruthenium complexes with substituted phenylpyridines

We have developed a new strategy that uses the Kroehnke synthesis for the preparation of various substituted phenylpyridines in excellent yields (up to 88%). Starting with the appropriate commercially available acetophenone, a variety of phenylpyridines substituted by either electron-donating (i.e. methyl, methoxy) or -withdrawing groups (i.e. bromide, nitro) on the phenyl ring are obtained in a two-step synthesis. The corresponding functionalized cyclometalated ruthenium complexes can be prepared with unusually high yields by using methanol as reaction solvent. The electrochemical data of the complexes demonstrate the strong σ-donating character of the anionic phenylpyridine ligand. X-ray analyses of four complexes show a shortening of the Ru-C bond associated with the elongation of only one of the five Ru-N bonds (trans effect). Wiley-VCH Verlag GmbH & Co, KGaA, 2006.