53308-83-1 Usage
Description
L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.
Chemical Properties
White Crystalline Powder
Uses
Different sources of media describe the Uses of 53308-83-1 differently. You can refer to the following data:
1. Reagent to inhibit nitric oxide production in biological systems.
2. Nitric oxide synthase inhibitor
Biological Activity
Competitive, irreversible inhibitor of all three NOS isoforms.
Biochem/physiol Actions
NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 53308-83-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,0 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53308-83:
(7*5)+(6*3)+(5*3)+(4*0)+(3*8)+(2*8)+(1*3)=111
111 % 10 = 1
So 53308-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/p+1/t5-/m0/s1
