53324-36-0

Basic information

• Product Name: 5-(4-IODOPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(4-IODOPHENYL)-1H-TETRAZOLE
• CAS NO: 53324-36-0
• Molecular Formula: C₇H₅IN₄
• Molecular Weight: 272.04587
• Mol File: 53324-36-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 269～271℃(dec)
• Appearance: /
• CAS DataBase Reference: 5-(4-IODOPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-IODOPHENYL)-1H-TETRAZOLE(53324-36-0)
• EPA Substance Registry System: 5-(4-IODOPHENYL)-1H-TETRAZOLE(53324-36-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53324-36-0(Hazardous Substances Data)

Upstream product

• 3956-07-8 4-iodobenzamide 
• 3058-39-7 4-iodobenzonitrile 

Downstream Products

• 1631160-89-8 5-{4-[2-[3,4,5-tris(octyloxy)phenyl]ethynyl]phenyl}-2H-tetrazole 
• 1631160-90-1 5-[4-(2-{4-[2-[3,4,5-tris(octyloxy)phenyl]ethynyl]phenyl}ethynyl)phenyl]-2H-tetrazole 
• 1631160-87-6 5-[4-(2(p-(hexyloxy)phenyl)ethynyl)phenyl]-2H-tetrazole 
• 1631160-93-4 tris{4-[2-(4-hexyloxyphenyl)ethynyl]phenyl}tris[1,2,4]triazolo[4,3-a:4',3'-c:4'',3''-e][1,3,5]triazine 
• 1631160-88-7 5-{4-[2-(4-didodecylaminophenyl)ethynyl]phenyl}-2H-tetrazole 
• 623907-47-1 2-(chloromethyl)-5-(4-iodophenyl)-1,3,4-oxadiazole 
• 120819-26-3 5-(4-iodo-phenyl)-1-methyl-1H-tetrazole 
• 120819-28-5 5-(4-iodo-phenyl)-2-methyl-2H-tetrazole 

Relevant articles and documents

Synthesis, structure, and antiviral properties of novel 2-adamantyl-5-aryl-2H-tetrazoles

[Figure not available: see fulltext.] The reaction of 5-aryl-NH-tetrazoles with adamantan-1-ol in concentrated sulfuric acid proceeds regioselectively with the formation of the corresponding 2-adamantyl-5-aryl-2H-tetrazoles. Nitration of these compounds l

ANTIVIRAL COMPOUNDS AND USE THEREOF

The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

Iron salts in the catalyzed synthesis of 5-substituted 1H-tetrazoles

A study was conducted to investigate the presence of iron salts in the catalyzed synthesis of 5-substituted 1H-tetrazoles. Para-trifluorotoluonitrile and trimethylsilyl azide were selected as model substrates for the initial metal source screening and the optimization of the reaction conditions. It was observed that the catalysis proceeded successfully producing tetrazole in 91% yield. A screening of various iron salts revealed that both the oxidation state of the iron and the counterion had a minor effect on the catalysis. Iron sources with different purity grades obtained from various providers were applied to investigate that the catalysis was not resulting from trace impurities in the metal salt. It was also observed that the catalysis proceeded successfully for a wide variety of aryl nitriles, providing tetrazoles in high yields. The best catalysis results were achieved with compounds that contained electron-withdrawing groups.