5333-42-6 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 5333-42-6 differently. You can refer to the following data:
1. 2-Octyl-1-dodecanol is clear, colourless or yellowish, oily liquid.
2. Octyldodecanol occurs as a clear, colorless, or yellowish, oily liquid.
Uses
Different sources of media describe the Uses of 5333-42-6 differently. You can refer to the following data:
1. 2-Octyl-1-dodecanol have been used as a emulsion stabilizer for polymer matrix patches.
2. 2-Octyldodecane-1-ol have been used as a emulsion stabilizer for polymer matrix patches.
3. 2-Octyl-1-dodecanol may be used to investigate its interaction with the hexameric capsules of resorcin[4]arene. It has been used as diluent in a extractant screening study for the recovery of putrescine (butylene-1,4-diamine, BDA) and cadaverine (pentylene-1,5-diamine, PDA) from aqueous solutions (fermentation broths) by liquid-liquid extraction.
Production Methods
2-Octyl-1-dodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Octyldodecanol is widely used in cosmetics and pharmaceutical
applications as an emulsifying and opacifying agent. It is primarily
used in topical applications because of its lubricating and emollient
properties.
Octyldodecanol has been used in the preparation of oil/water
microemulsions investigated as the vehicle for the dermal administration
of drugs having no or low skin penetration.Octyldodecanol
has also been evaluated as a solvent for naproxen when
applied topically.Studies of estimated permeability coefficient
suggest that octyldodecanol could be a potential dermal permeation
enhancer.
Safety Profile
An eye and severe skin irritant.When heated to decomposition it emits acrid smoke andirritating vapors.
Safety
Octyldodecanol is widely used in cosmetics and topical pharmaceutical
formulations, and is generally regarded as nontoxic and
nonirritant at the levels employed as an excipient.
In acute oral toxicity studies in rats fed 5 g/kg of undiluted
octyldodecanol, no deaths were observed.In an acute dermal
toxicity study, intact and abraded skin sites of guinea pigs were
treated with 3 g/kg of undiluted octyldodecanol under occlusive
patches; no deaths occurred and no gross skin lesions were
observed.Octyldodecanol caused either no ocular irritation or
minimal, transient irritation in the eyes of rabbits.However, some
sources describe undiluted octyldodecanol as an eye and severe skin
irritant.
storage
The bulk material should be stored in a well-closed container in a
cool, dry place, protected from light. In the original unopened
container, octyldodecanol can be stored for 2 years protected from
moisture at below 30°C.
Incompatibilities
2-Octyl-1-dodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical,
transdermal, and vaginal preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 5333-42-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,3 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5333-42:
(6*5)+(5*3)+(4*3)+(3*3)+(2*4)+(1*2)=76
76 % 10 = 6
So 5333-42-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H42O/c1-3-5-7-9-11-12-13-15-17-19-20(21)18-16-14-10-8-6-4-2/h20-21H,3-19H2,1-2H3
5333-42-6Relevant articles and documents
Ir(NHC)-Catalyzed Synthesis of β-Alkylated Alcohols via Borrowing Hydrogen Strategy: Influence of Bimetallic Structure
Sung, Kihyuk,Lee, Mi-hyun,Cheong, Yeon-Joo,Kim, Yu Kwon,Yu, Sungju,Jang, Hye-Young
supporting information, p. 3090 - 3097 (2021/05/10)
Multi N-heterocyclic carbene(NHC)-modified iridium catalysts were employed in the β-alkylation of alcohols; dimerization of primary alcohols (Guerbet reaction), cross-coupling of secondary and primary alcohols, and intramolecular cyclization of alcohols. Mechanistic studies of Guerbet reaction, including kinetic experiments, mass analysis, and density functional theory (DFT) calculation, were employed to explain the fast reaction promoted by bimetallic catalysts, and the dramatic reactivity increase of monometallic catalysts at the late stage of the reaction. (Figure presented.).
Preparation method and application of bifurcated halogenated alkyl chain compounds
-
Paragraph 0104; 0105; 0106; 0107, (2018/11/26)
The invention discloses a preparation method and an application of bifurcated halogenated alkyl chain compounds. The method comprises the following steps: reacting bromoalkane with dimethyl malonate to obtain single-branch dimethyl malonate; reacting bromoalkane with the obtained single-branch dimethyl malonate to obtain two-branch dimethyl malonate; carrying out selective hydrolysis decarboxylation on the two-branch dimethyl malonate to obtain a hydrolysate; reducing the hydrolysate to obtain primary alcohol; carrying out a bromination reaction on the primary alcohol to obtain a brominated product; reacting the brominated product with ethylene oxide to obtain carbon chain-extended primary alcohol compounds; and carrying out a halogenation reaction on the carbon chain-extended primary alcohol compounds to obtain the bifurcated halogenated alkyl chain compounds with R being a corresponding halogen atom. The method has the advantages of low cost, high yield, simplicity in operation, andeasiness in realization of industrialization. Alkyl chains with different bifurcated lengths are introduced to an organic conjugated polymer, so the pi-pi piling distance between polymers is effectively reduced, the mobility of the polymer is improved.
Synthetic base stock based on Guerbet alcohols
Waykole, Chetan,Bhowmick, Diptinarayan,Pratap, Amit
, p. 1407 - 1416 (2014/08/18)
Guerbet (β branched) alcohols of varying chain length of even carbon numbers were synthesized by using single linear fatty alcohols ranging from 1-octanol to 1-dodecanol. All Guerbet alcohols having fewer than 28 carbon atoms and are liquid at 0 °C due to β branching. Synthetic base oils were prepared by reacting commonly available unsaturated fatty acids and dicarboxylic acids with Guerbet alcohols using p-toluenesulfonic acid as a catalyst. These base oils were characterized by physical and tribological properties like viscosity, viscosity index, pour point, flash point, wear scar, weld load, coefficient of friction etc. and compared with commercially available 150 and 500 N base oils.
