53336-38-2

Upstream product

• 110-91-8 morpholine 
• 83-25-0 N-phenylmaleimide 
• 62-53-3 aniline 
• 941-69-5 N-phenyl-maleimide 

Downstream Products

• 94740-59-7 3-Morpholin-4-yl-1-phenyl-5-thioxo-1,5-dihydro-pyrrol-2-one 
• 117840-64-9 3-Nitrophenyl-(2'-hydroxy-N'-phenyl-maleinimid-3'-yl)-<2-hydroxy-N-(4-methylphenyl)-maleinimid-3-yl>-methan 
• 56414-19-8 4-morpholin-4-yl-2,5-dioxo-1-phenyl-2,5-dihydro-pyrrole-3-carboxylic acid benzoylamide 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Thioamination of Maleimides with Amines and Bunte Salts

Herein, we describe the first example of copper-catalyzed oxidative thioamination of maleimides with secondary amines and Bunte salts with the achievement of C-N and C-S bonds in a single flask. The protocol showcases a prominently broad substrate scope a

Oxidative Aminoarylselenation of Maleimides via Copper-Catalyzed Four-Component Cross-Coupling

The first example of copper-catalyzed four-component coupling reaction of aryl iodides, Se powder, secondary amines, and maleimides is developed. This reaction provides an efficient and concise route to access aminoarylselenated maleimides via double C-Se bonds and C-N bond formation. The appealing features of this transformation are the use of Se powder as a selenating reagent, a green catalytic system, a wide range of substrate scope, and late-stage selenation of bioactive compounds.

Synthesis of novel N-aryl-3-dialkylamino-4-substituted maleimides

The syntheses of several novel 3-dialkylamino-N-aryl-maleimides 3a-i and 6 are described via a conjugate elimination addition-elimination pathway. Syntheses of their various 4-substituted derivatives 4a-i, 5a-c and 7-12 are also described. Introduction of a secondary amino group at C-3 position in N-arylmaleimides leads to the formation of enaminones 3a-i and 6, which undergo facile electrophilic substitutions at C-4 position in good to excellent yields to provide the highly functionalized maleimides 4a-i, 5a-c and 7-12.