5334-72-5Relevant academic research and scientific papers
Preparation method of pyrazolopyrimidine compound intermediate
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Paragraph 0040-0042; 0043, (2018/03/24)
The invention relates to medicine intermediates and especially provides a synthesis method of a pyrazolopyrimidine hydrazine compound. On the basis of the prior art, NaI or KI is added during a hydrazinolysis reaction, so that yield and purity in the hydrazinolysis reaction are increased. The method has gentle reaction conditions, high reaction yield and product purity, is low in production cost,and is suitable for industrial large-scale production.
Synthesis method of pyrazolopyrimidine compounds
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Paragraph 0034; 0042; 0044, (2018/05/16)
The invention relates to a synthesis method of pyrazolopyrimidine compounds. On the basis of the prior art, sodium iodide or potassium iodide is introduced to a hydrazinolysis reaction, the yield andthe purity are increased through the hydrazinolysis step, and accordingly, the total yield is increased. The method has the advantages of mild reaction conditions, high reaction yield and purity, lowproduction cost and the like, and is suitable for production on an industrialization scale.
A pyrazolo pyrimidine compound and use thereof
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Paragraph 0096-0098, (2017/11/16)
The invention discloses a compound shown in general formula I and an application thereof as a plant disease-resistant activator, wherein R1 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 halogenated alkyl, C3-C6 naphthenic base, halogen, nitro and hydroxyl; R2 is independently selected from C1-C6 alkyl, C1-C6 halogenated alkyl, hydroxyl, C1-C6 alkoxy, C1-C6 halogenated alkoxy, substituted or unsubstituted C6-C14 aryl, halogen, nitro, amino, C1-C6 alkoxy, carboxyl, C1-C3 alcoxyl formyl and pentabasic or hexahydric nitrogen and heterocyclic ring of oxygen or sulfur-containing; n is selected from 0-5. The compound is used for inhibiting the pathogens through inducing the plants to generate disease resistance, rather than directly killing or inhibiting the pathogens; the compound has the advantages of systematicness, long-lasting effect, broad spectrum and safety, so that the dosage of highly toxic pesticide can be reduced, and environment friendliness, great industrial/commercial prospect and market value are achieved.
A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
Dolzhenko, Anton V.,Pastorin, Giorgia,Dolzhenko, Anna V.,Chui, Wai Keung
scheme or table, p. 5617 - 5621 (2011/02/24)
A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of th
Pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine
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, (2008/06/13)
New pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidines have the general formula STR1 They are useful as antiinflammatory agents.
