53344-76-6Relevant academic research and scientific papers
A one-pot, single-solvent process for tandem, catalyzed C-H borylation-Suzuki-Miyaura cross-coupling sequences
Harrisson, Peter,Morris, James,Steel, Patrick G.,Marder, Todd B.
experimental part, p. 147 - 150 (2009/05/30)
Methyl tert-butyl ether is a suitable solvent for iridium-catalyzed C-H borylation followed, in the same pot, by palladium-catalyzed Suzuki-Miyaura cross-coupling sequences, giving high yields of biaryls. Georg Thieme Verlag Stuttgart.
ON THE BIPYRIDYL FORMATION IN REACTIONS OF 2-CHLOROPYRIDINE DERIVATIVES WITH POTASSIUM AMIDE IN LIQUID AMMONIA
Streef, Johannis W.,Plas, Henk C. van der,Harkema, Sybolt
, p. 2313 - 2325 (2007/10/02)
In the reaction of 2,6-dichloropyridine and 2,6-dichloro-3-phenylpyridine with potassium amide in liquid ammonia at -70 deg C, formation of derivatives of 4,4'-bipyridyl and 3,4'-bipyridyl is observed.The 4,4' coupling products are far in excess to the 3,4' coupling products.When the reaction is carried out at -70 deg C in the presence of potassium permanganate, the corresponding 4-aminopyridines are the main products. 2-Chloro-6-phenoxypyridine is very unreactive with this aminating reagent at -70 deg C as well as -33 deg C, but in the presence of potassium permanganate at -33 deg C 4-amino-2-chloro-6-phenoxypyridine is formed in fair yield.The mechanisms of the formation of the bipyridyls and 4-aminopyridines are presented.
