53380-19-1Relevant academic research and scientific papers
An asymmetric aerobic aza-Wacker-type cyclization: Synthesis of isoindolinones bearing tetrasubstituted carbon stereocenters
Yang, Guoqiang,Shen, Chaoren,Zhang, Wanbin
, p. 9141 - 9145 (2012/11/07)
It's all in the solvent: An enantioselective variant of an aza-Wacker-type cyclization that gives isoindolinones containing tetrasubstituted carbon centers α to the nitrogen atom has been developed (see scheme; tfa=trifluoroacetate). The use of a highly coordinating solvent is crucial for the activity of the catalyst and the stereoselectivity the reaction (up to 99 % ee). Copyright
