53382-80-2

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 62-53-3 aniline 

Downstream Products

• 183055-93-8 N-bis(2-chloroethyl)-N'-(4-methoxyphenyl)-N''-phenylphosphotriamidate 
• 183055-95-0 [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-phenyl-amine 
• 183056-01-1 1-(4-Methoxy-phenyl)-7-phenyl-tetrahydro-[1,3,2]diazaphospholo[1,2-a][1,3,2]diazaphosphole 8-oxide 

Relevant academic research and scientific papers

Preparation of acyclic and cyclic phosphoric triamides and diamido esters

Using phosphoryl chloride as a substrate, a series of N-bis(2-chloroethyl)phosphoric triamides (and diamido esters) was prepared. These acyclic products were cyclized to the 1,3,2-diazaphospholidine derivatives, which, in turn, could be cyclized again to

SYNTHESIS AND PROPERTIES OF NOVEL NITROGEN MUSTARD LINKED PHOSPHORYL DIAMIDE DERIVATIVES

Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed.All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis.Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).Key words: Antitumor; antivirus; phosphoryl diamide; nitrogen mustard.