53384-26-2

Upstream product

• 61-78-9 p-Aminohippuric acid 
• 463-71-8 thiophosgene 

Downstream Products

• 1446010-81-6 2-(4-(3-(4-(N-pyridin-2-ylsulfamoyl)phenyl)thioureido)benzamido)acetic acid 
• 1446010-82-7 2-(4-(3-(4-(N-pyrimidin-2-ylsulfamoyl)phenyl)thioureido)benzamido)acetic acid 
• 1446010-85-0 2-(4-(3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)thioureido)benzamido)acetic acid 
• 1446010-86-1 2-(4-(3-(4-carbamoyl-3-(phenylamino)-1H-pyrazol-5-yl)thioureido)benzamido)acetic acid 
• 1446010-87-2 2-(4-(3-(3-amino-4-((4-chlorophenyl)diazenyl)-1H-pyrazol-5-yl)thioureido)benzamido)acetic acid 
• 1446010-89-4 2-(4-(2-benzoylhydrazinecarbothioamido)benzamido)acetic acid 
• 1446010-90-7 2-(4-(2-isonicotinylhydrazinecarbothioamido)benzamido)acetic acid 
• 1446010-91-8 2-(4-(2-(phenylsulfonyl)hydrazinecarbothioamido)benzamido)acetic acid 
• 1446010-83-8 C₁₉H₁₈N₄O₆S 
• 1446010-84-9 C₂₆H₂₄N₆O₆S₂ 
• 1446010-68-9 2-(4-(3-butylthioureido)benzamido)acetic acid 
• 1446010-69-0 2-(4-(3-cyclohexylthioureido)benzamido)acetic acid 
• 59440-81-2 2-(4-(3-phenylthioureido)benzamido)acetic acid 
• 1446010-72-5 2-(4-(3-(3-fluorophenyl)thioureido)benzamido)acetic acid 

Relevant academic research and scientific papers

Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activities

New series of thiourea derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of 4-hippuric acid isothiocyanate with various nitrogen nucleophiles such as aliphatic amines, aromatic amines, sulfa drugs, aminopyrazoles, phenylhydrazine and hydrazides. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(3-(3-bromophenyl)thioureido)benzamido)acetic acid and 2-(4-(3-(4-(N-pyrimidin-2-ylsulfamoyl)phenyl)thioureido)benzamido)acetic acid, showed significant antibacterial and antifungal activities. These compounds comprise a new class of promising broad-spectrum antibacterial and antifungal agents.