533882-54-1Relevant academic research and scientific papers
Controllable synthesis of pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives through multi-component reactions in ionic Liquid
Zhang, Xinying,Li, Xiaoyan,Fan, Xuesen,Wang, Xia,Wang, Jianji,Qu, Guirong
, p. 382 - 388 (2009)
A multi-component reaction of aldehyde, malononitrile, and 5-amino-3-methyl-1-phenylpyrazole was carried out smoothly in [bmim][BF 4] without any added catalyst. Through this reaction, pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives were obtained conveniently and controllably at different temperatures. The ionic liquid used can be easily recovered and efficiently reused for at least five runs.
