53389-89-2Relevant academic research and scientific papers
Synthesis and antiacetylcholinesterase activity evaluation of new 2-aryl benzofuran derivatives
Pouramiri, Behjat,Mahdavi, Mohammad,Moghimi, Setareh,Firoozpour, Loghman,Nadri, Hamid,Moradi, Alireza,Tavakolinejad-Kermani, Esmat,Asadipour, Ali,Foroumadi, Alireza
, p. 897 - 902 (2016/10/31)
Starting from 2-hydroxybenzyl alcohol, a series of 2-arylbenzofurans have been synthesized and evaluated as acetylcholinesterase inhibitors at 23 μM by using modified colorimetric Ellman's method. The reaction sequence was completed in four steps. All of the fourteen synthesized products were obtained in excellent yields without the need to tedious work-up step. In the last step, different derivatives were obtained by the substitution of bromine with five and six-membered cyclic and acyclic amines. Among the synthesized compounds, the best activity was observed in 1-(4-(Benzofuran-2-yl) benzyl)piperidine 5c with 74% activity compared to donepezil as a reference drug.
Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates
Baziard-Mouysset, G.,Tchani, G. W.,Stigliani, J. L.,Payard, M.,Bonnafous, R.,Tisne-Versailles, J.
, p. 539 - 546 (2007/10/02)
In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter.Three diethyl 4-(2
