533893-84-4Relevant academic research and scientific papers
Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists
Kambe, Tohru,Maruyama, Toru,Nakano, Masayuki,Yamaura, Yoshiyuki,Shono, Tomoyuki,Seki, Akiteru,Sakata, Kiyoto,Maruyama, Takayuki,Nakai, Hisao,Toda, Masaaki
, p. 1523 - 1534 (2012/01/13)
Analogs 8-aza-16-aryl prostaglandin E1 (PGE1) and 8-aza-5-thia-16-arylPGE1 were synthesized and evaluated with respect to their subtype receptor affinity and EP4 agonist activity for the purposes of identifying sub-type- selective EP
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.
Elworthy, Todd R,Kertesz, Denis J,Kim, Woongki,Roepel, Michael G,Quattrocchio-Setti, Lina,Smith, David B,Tracy, Jahari Laurant,Chow, Audrey,Li, Fujun,Brill, Emma R,Lach, Leang K,McGee, Daren,Yang, Diana S,Chiou, San-San
, p. 1655 - 1659 (2007/10/03)
A series of 7-[(5R)-substituted 2-oxo-1-pyrrolidinyl]-heptanoic acids were prepared, their isomeric purity determined, and pharmacologically evaluated. Lactams with affinity for the EP(4) receptor displayed agonist behavior. The lower side-chain of the la
