53391-42-7

Basic information

• Product Name: 5-nitro-2-(trichloroacetyl)-1-methylpyrrole
• CAS NO: 53391-42-7
• Molecular Weight: 271.487
• Mol File: 53391-42-7.mol

Chemical Properties

• CAS DataBase Reference: 5-nitro-2-(trichloroacetyl)-1-methylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-2-(trichloroacetyl)-1-methylpyrrole(53391-42-7)
• EPA Substance Registry System: 5-nitro-2-(trichloroacetyl)-1-methylpyrrole(53391-42-7)

Safety Data

• Hazardous Substances Data: 53391-42-7(Hazardous Substances Data)

Upstream product

• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 

Downstream Products

• 13138-75-5 N-methyl-5-nitropyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of distamycin a polyamides targeting G-quadruplex DNA

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode. The Royal Society of Chemistry 2006.

Efficient synthesis of oligo-N-methylpyrrolecarboxamides and related compounds

1-Methyl-4-nitro-2-trichloroacetylpyrrole 5, a new precursor for the syntheses of oligo-N-methylpyrrolecarboxamide antibiotics and their analogues, was prepared with facility. The versatility of 5 was demonstrated by the syntheses of oligopeptides 16-19.