533934-74-6

Downstream Products

• 150607-94-6 methyl 1,2,3,4-tetra-O-isobutyryl-β-D-glucopyranuronate 
• 34096-83-8 1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid 
• 150608-11-0 methyl 1,2,3,4-tetra-O-benzoyl-β-D-glucopyranuronate 
• 7355-18-2 (2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 1184951-56-1 methyl 6-([4-([1-(tert-butyl)-1,1-dimethylsilyl]oxymethyl)anilino]carbonyloxy)-3,4,5-trihydroxytetrahydro-2H-2-pyrancarboxylate 

Relevant academic research and scientific papers

Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: A novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro

A new oleanane-type saponin oleiferasaponin C6 (OSC6) was isolated and identified from Camellia oleifera seeds through NMR, HR-ESI-MS, and GC-MS spectroscopic methods. This new oleanane-type saponin exhibits potent cytotoxic activities on five human cancer cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB), especially in HL-60 and BEL-7402 cell lines. The action mechanism of the anti-cancer activity of OSC6 was further investigated and it showed significant induction of cell cycle arrest and apoptosis in HL-60 and BEL-7402 cell lines by down-regulating CDK4, cyclin D1 and Bcl-2; up-regulating p21, caspase-3/9, p-p53 and Bax protein expression in vitro. These results suggested that the newly isolated saponin OSC6 is a potential therapeutic agent for the treatment of human cancer.