533939-03-6

Basic information

• Product Name: Propanamide, N-(6-ethyl-3-methyl-2-pyridinyl)-2,2-dimethyl- (9CI)
• Synonyms: Propanamide, N-(6-ethyl-3-methyl-2-pyridinyl)-2,2-dimethyl- (9CI)
• CAS NO: 533939-03-6
• Molecular Formula: C13H20N2O
• Molecular Weight: 220.3107
• Product Categories: ETHYL
• Mol File: 533939-03-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanamide, N-(6-ethyl-3-methyl-2-pyridinyl)-2,2-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-(6-ethyl-3-methyl-2-pyridinyl)-2,2-dimethyl- (9CI)(533939-03-6)
• EPA Substance Registry System: Propanamide, N-(6-ethyl-3-methyl-2-pyridinyl)-2,2-dimethyl- (9CI)(533939-03-6)

Safety Data

• Hazardous Substances Data: 533939-03-6(Hazardous Substances Data)

Upstream product

• 533939-02-5 N-(6-ethyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications

Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acid aldose reductase inhibitors. The lead candidate, [6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyri din-1-yl]acetic acid example 16, inhibits aldose reductase with an IC50 of 8 nM, while being inactive against aldehyde reductase (IC50 > 100 μM), a related enzyme involved in the detoxification of reactive aldehydes.