5341-58-2Relevant articles and documents
A new acylhydrazine N'-(1,3 dimethylbutylene)-3-hydroxy-naphthohydrazide based fluorescent sensor for the detection of Ni2+
Duan, Abing,Li, Junhua,Liu, Mengqin,Luo, Chunhua,Peng, Hui,Tan, Yuxing,Yin, Zipeng
, (2020)
In this paper, a novel hydrazide compound (N'-(1,3 dimethylbutylene)-3-hydroxy-naphthohydrazide) (BMH) was synthesized by a simple three-stage reaction and its chemical structure was confirmed by 1H NMR, 13C NMR and FTIR characterization. This compound was used as fluorescent sensor for the detection of Ni2+ based on photoluminescence quenching. The fluorescence quenching of BMH upon the addition of Ni2+ is due to the formation of coordination complex which was verified by bind model and density functional theory studies. The Ni2+ concentration dependent fluorescence quenching efficiency of BMH was examined and the detection conditions were optimized. There is a good linear relationship between the emission intensity quenching (ΔF = F0–F) and the Ni2+ concentration (c) between 80 nM and 2 μM and the detection limit is 60 nM. The simple preparation of the compound BMH and the high sensitivity of the fluorescent sensor hold great promise for the determination of Ni2+ in environment.
A simple chemosensor for the dual-channel detection of cyanide in water with high selectivity and sensitivity
Cheng, Xiao-Bin,Li, Hui,Zheng, Feng,Lin, Qi,Yao, Hong,Zhang, You-Ming,Wei, Tai-Bao
, p. 27130 - 27135 (2016)
We have synthesized a simple chemosensor (HY) of acylhydrazones and used it for colorimetric detection of cyanide anions (CN-) in DMSO/H2O (3:7, v/v) mixed solvent. The simple chemosensor displays a specificity response for cyanide over other common anions (F-, Cl-, Br-, I-, AcO-, H2PO4-, HSO4-, ClO4-, and SCN-) in mixed solution. Upon treatment with cyanide, HY displayed a remarkable naked-eye and fluorogenic response, simultaneously with significant changes in its UV-visible and fluorescence spectra. Furthermore, competitive anions did not show any significant changes both in colour and emission intensity, indicating the high selectivity of the sensor to CN-. The absorption spectra detection limit of the chemosensor for cyanide was 8.34 × 10-7 M and the fluorescence spectra detection limit was 2.85 × 10-8 M. The cyanide test strips based on the chemosensor could serve as a convenient cyanide test kit. Furthermore, the chemosensor was successfully applied to the detection of cyanide in sprouting potatoes.
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis
Kant, Rajni,Yang, Ming-Hui,Tseng, Chih-Hua,Yen, Chia-Hung,Li, Wei-You,Tyan, Yu-Chang,Chen, Marcelo,Tzeng, Cherng-Chyi,Chen, Wei-Cheng,You, Kaiting,Wang, Wen-Chieh,Chen, Yeh-Long,Chen, Yi-Ming Arthur
, p. 8992 - 9009 (2021/07/19)
Glycine-N-methyl transferase (GNMT) downregulation results in spontaneous hepatocellular carcinoma (HCC). Overexpression of GNMT inhibits the proliferation of liver cancer cell lines and prevents carcinogen-induced HCC, suggesting that GNMT induction is a potential approach for anti-HCC therapy. Herein, we used Huh7 GNMT promoter-driven screening to identify a GNMT inducer. Compound K78 was identified and validated for its induction of GNMT and inhibition of Huh7 cell growth. Subsequently, we employed structure-activity relationship analysis and found a potent GNMT inducer, K117. K117 inhibited Huh7 cell growth in vitro and xenograft in vivo. Oral administration of a dosage of K117 at 10 mpk (milligrams per kilogram) can inhibit Huh7 xenograft in a manner equivalent to the effect of sorafenib at a dosage of 25 mpk. A mechanistic study revealed that K117 is an MYC inhibitor. Ectopic expression of MYC using CMV promoter blocked K117-mediated MYC inhibition and GNMT induction. Overall, K117 is a potential lead compound for HCC- and MYC-dependent cancers.
Preparation of Acifluorfen-Based Ionic Liquids with Fluorescent Properties for Enhancing Biological Activities and Reducing the Risk to the Aquatic Environment
Cao, Yongsong,Li, Jianqiang,Niu, Junfan,Tang, Gang,Tang, Jingyue,Tang, Rong,Yang, Jiale,Zhang, Wenbing,Zhou, Zhiyuan
, p. 6048 - 6057 (2020/06/26)
In this work, 12 novel herbicidal ionic liquids (HILs) based on acifluorfen were prepared by pairing with the fluorescent hydrazides or different alkyl chains for increasing activities and reducing negative impacts on the aquatic environment. The results showed that the fluorescence of coumarin hydrazide in the HILs was applied as the internal and supplementary light source to meet the requirement of light wavelength range of acifluorfen, which improved the phytotoxicity of acifluorfen to weeds by enhancing singlet oxygen generation with increased sunlight utilization. The herbicidal activities of HILs were related positively with the length of chain of cation under high light intensity and depended mainly on the fluorescence characteristic of the cation under low light intensity, and the double salt IL forms of acifluorfen containing coumarin hydrazide and n-hexadecyltrimethylammonium had enhanced efficacies against broadleaf weeds in the field. Compared with acifluorfen sodium, HILs had lower water solubility, better surface activity, weaker mobility in soils, and higher decomposition temperature. These results demonstrated that HILs containing different cations provided a wider scope for fine-tuning of the physicochemical and biological properties of herbicides and established a promising way for the development of environmentally friendly herbicidal formulations.
