53411-80-6Relevant articles and documents
Electrochemical Nitration with Nitrite
Blum, Stephan P.,Nickel, Christean,Sch?ffer, Lukas,Karakaya, Tarik,Waldvogel, Siegfried R.
, p. 4936 - 4940 (2021/10/25)
Aromatic nitration has tremendous importance in organic chemistry as nitroaromatic compounds serve as versatile building blocks. This study represents the electrochemical aromatic nitration with NBu4NO2, which serves a dual role as supporting electrolyte and as a safe, readily available, and easy-to-handle nitro source. Stoichiometric amounts of 1,1,1-3,3,3-hexafluoroisopropan-2-ol (HFIP) in MeCN significantly increase the yield by solvent control. The reaction mechanism is based on electrochemical oxidation of nitrite to NO2, which initiates the nitration reaction in a divided electrolysis cell with inexpensive graphite electrodes. Overall, the reaction is demonstrated for 20 examples with yields of up to 88 %. Scalability is demonstrated by a 13-fold scale-up.
Pyrimidine derivatives Anaplastic lymphoma kinase inhibitors
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Paragraph 0210; 0212; 0213; 0214, (2018/07/30)
The invention belongs to the technical filed of medicines, and concretely relates to pyrimidine derivative anaplastic lymphoma kinase inhibitors represented by general formula (I), or stereoisomers, or pharmaceutically acceptable salts or esters or solvat
POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR
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Paragraph 0166; 0167; 0189; 0190; 0220; 0221, (2018/02/06)
Provided is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R1, R2, R3, R4, and ring A are as defined in the description. The invention also relates to a method for preparing the compound, a pharmaceutical preparation and a pharmaceutical composition comprising the compound, and use of the compound, the pharmaceutically acceptable salt or stereoisomer thereof in manufacture of a medicament for the treatment and/or prevention of an anaplastic lymphoma kinase-mediated cancer or non-cancer related diseases.
Triazine derivative anaplastic lymphoma kinase inhibitor
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Paragraph 0163; 0164; 0165, (2017/01/02)
The invention belongs to the technical field of medicines, and particularly relates to a triazine derivative anaplastic lymphoma kinase inhibitor shown in a general formula (I), pharmaceutically acceptable salt, ester, solvate or stereoisomer of the inhibitor. R1, R2, R3, R4, R6, R7 and A rings are defined in the description. The invention further relates to a preparation method of compounds, a medicinal preparation containing the compounds, a medicine combination containing the compounds and an application of the compounds, the pharmaceutically acceptable salt, ester, solvate or stereoisomer to preparation of a medicine for treating and/or preventing anaplastic lymphoma kinase-mediated cancer-related diseases.
A new method for the mononitration of phenol derivatives by poly(4-vinylpyridinium nitrate) and silica sulfuric acid under mild conditions
Goudarziafshar, Hamid
experimental part, p. 458 - 461 (2012/06/18)
This procedure works efficiently for high selective mono nitration of phenol and substituted phenol to corresponding nitro compounds in moderate to high yield using poly(4-vinylpyridinium nitrate) and silica sulfuric acid in dichloromethane at room temperature.
A mild procedure for the preparation of o-nitrophenols by nitro urea or ammonium nitrate in the presence of silica sulfuric acid (SiO 2-OSO3H)
Ghorbani-Choghamarani, Arash,Nikoorazm, Mohsen,Goudarziafshar, Hamid,Naserifar, Zahra,Zamani, Parisa
experimental part, p. 731 - 734 (2011/11/12)
A mixture of ammonium nitrate or nitro urea and silica sulfuric acid was found to be efficient and environmentally friendly nitrating media for the preparation of orto-nitro phenols in dichloromethane at room temperature. A mixture of ammonium nitrate or nitro urea and silica sulfuric acid was found to be efficient and environmentally friendly nitrating media for the preparation of orto-nitro phenols in dichloromethane at room temperature.
Aluminum nitrate and silica sulfuric acid as efficient nitrating media for the mononitration of phenols under mild and heterogeneous conditions
Ghorbani-Choghamarani, Arash,Goudarziafshar, Hamid,Nikoorazm, Mohsen,Yousefi, Somaieh
experimental part, p. 1144 - 1147 (2009/10/23)
A variety of phenol derivatives were successfully nitrated via combination of Al(NO3)3-9H2O and silica sulfuric acid in the presence of wet SiO2 (50% w/w) in dichloromethane at room temperature with moderate-to-good yields.
