53429-02-0Relevant academic research and scientific papers
Copper-Catalyzed N?F Bond Activation for Uniform Intramolecular C?H Amination Yielding Pyrrolidines and Piperidines
Bafaluy, Daniel,Mu?oz-Molina, José María,Funes-Ardoiz, Ignacio,Herold, Sebastian,de Aguirre, Adiran J.,Zhang, Hongwei,Maseras, Feliu,Belderrain, Tomás R.,Pérez, Pedro J.,Mu?iz, Kilian
, p. 8912 - 8916 (2019)
The dual function of the N?F bond as an effective oxidant and subsequent nitrogen source in intramolecular aliphatic C?H functionalization reactions is explored. Copper catalysis is demonstrated to exercise full regio- and chemoselectivity control, which
Efficient and convenient heterogeneous palladium-catalyzed regioselective deuteration at the benzylic position
Kurita, Takanori,Hattori, Kazuyuki,Seki, Saori,Mizumoto, Takuto,Aoki, Fumiyo,Yamada, Yuki,Ikawa, Kanoko,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
, p. 664 - 673 (2008/12/21)
The Pd/C-catalyzed efficient and regioselective hydrogen-deuterium (H-D) exchange reaction on the benzylic site proceeded in D2O in the presence of a small amount of H2 gas. The use of the Pd/C-ethylenediamine complex [Pd/C(en)] as a catalyst instead of Pd/C led to the efficient deuterium incorporation into the benzylic site of Obenzyl protective groups without hydrogenolysis. These H-D exchange reactions provide a post synthetic and D2-gas-free deuterium-labeling method on a wide variety of benzylic sites using D2O as the deuterium source and heterogeneous Pd/C or Pd/C(en) as a reusable heterogeneous palladium catalyst under mild and neutral conditions.
