5345-94-8Relevant articles and documents
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS
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Paragraph 00700; 00709, (2019/01/08)
The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives
Taveira, Aline F.,Hyaric, Mireille Le,Reis, Elaine F.C.,Araujo, Debora P.,Ferreira, Ana Paula,de Souza, Maria Aparecida,Alves, Livia L.,Lourenco, Maria C.S.,Vicente, Felipe Rodrigues C.,de Almeida, Mauro V.
, p. 7789 - 7794 (2008/04/05)
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5 μg/mL. The presence of the carbohydrate slightly affected the antibacterial activity.