534560-89-9Relevant academic research and scientific papers
New synthesis of aryl and heteroaryl N-acylureas via microwave-assisted palladium-catalysed carbonylation
Liptrot, David,Alcaraz, Lilian,Roberts, Bryan
supporting information; experimental part, p. 2183 - 2188 (2010/11/04)
A new, practical synthesis of aryl and heteroaryl N-acylureas has been developed via palladium-catalysed carbonylation of aryl or heteroaryl halides in the presence of urea nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation, using either carbon monoxide gas in a vessel equipped with a gas inlet adapter, or molybdenum hexacarbonyl as the carbon monoxide source in standard microwave vials. The reactions proceeded in good to excellent yields. To illustrate the usefulness of this method a one-step synthesis of the important insecticide diflubenzuron is reported.
