534569-38-5

Upstream product

• 89839-87-2 2-(4-methylphenyl)-2,3-dihydro-4H-chromen-4-one 
• 563-41-7 semicarbazide hydrochloride 
• 34000-27-6 1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

Synthesis and cytotoxic activity of 4-aryl-4H-chromeno[4,3-d] [1,2,3] selenadiazoles

Fourteen 4-Aryl-4H-chromeno[4,3-d][1,2,3] selenadiazole derivatives were synthesized by the reaction of fla-vonone-4-semicarbazones with SeO2. The structures of the target compounds 1a-n were elucidated by 1H NMR, IR spectra, ESI-MS and elemental analyses. The preliminary cytotoxic activities of 1a-n against K562, KB, A549, SMC-7721 and SGC-7901 cell lines were evaluated by MTT method, indicating that most compounds displayed moderate to good antiproliferative activities against K562 and KB cell lines. Compounds 1m and 1n, the most potent ones, were promising template for development of novel potent antitumor agents.

Synthesis of newer selenadiazoles and thiadiazoles from their chroman-4-one precursors

A newer series of 13 compounds viz. 2-aryl-3,4-dihydrobenzopyrano [3, 4-d]-1, 2, 3-selenadiazoles 3 and 2-aryl-3,4-dihydrobenzopyrano (3,4-d)-1. 2, 3-thiadiazoles 4 have been synthesized from their chroman-4-one precursors.