534596-16-2Relevant academic research and scientific papers
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents
Nazare, Marc,Essrich, Melanie,Will, David W.,Matter, Hans,Ritter, Kurt,Urmann, Matthias,Bauer, Armin,Schreuder, Herman,Dudda, Angela,Czech, Joerg,Lorenz, Martin,Laux, Volker,Wehner, Volkmar
, p. 4191 - 4195 (2007/10/03)
A series of novel, highly potent 2-carboxyindole-based factor Xa inhibitors is described. Structural requirements for neutral ligands, which bind in the S1 pocket of factor Xa were investigated with the 2-carboxyindole scaffold. This privileged fragment assembly approach yielded a set of equipotent, selective inhibitors with structurally diverse neutral P1 substituents.
