53460-56-3Relevant academic research and scientific papers
Diazocinones: Synthesis and conformational analysis
Robins, Lori I.,Carpenter, Richard D.,Fettinger, James C.,Haddadin, Makhluf J.,Tinti, Dino S.,Kurth, Mark J.
, p. 2480 - 2485 (2007/10/03)
1,2,4,5-Tetrazines (prepared from aryl nitriles) condense with isoxazolylcyclobutanones (prepared from 3-benzenesulfonyl-3-vinylcyclobutanol) in methanolic KOH to give conformationally restricted 6-isoxazol-5-yl-6,7- dihydro-5H-[1,2]diazocin-4-ones. The s
Synthesis and antitumor activity of s-tetrazine derivatives
Hu, Wei-Xiao,Rao, Guo-Wu,Sun, Ya-Quan
, p. 1177 - 1181 (2007/10/03)
Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.
