53472-37-0

Usage

Uses

Used in Grape and Wine Authentication:
Laricitrin is used as a flavanol marker for grape and wine authentication. Its presence helps in profiling and distinguishing different varieties of grapes and wines, ensuring their authenticity and quality.
Used in Anticancer Applications:
Laricitrin is used as an anticancer agent, particularly in the inhibition of colon adenocarcinoma cell proliferation. It is involved in the G2/M cell cycle block and reduction in cyclin D1 expression, which contributes to the suppression of tumor growth and progression.

InChI:InChI=1/C16H12O8/c1-23-11-3-6(2-9(19)13(11)20)16-15(22)14(21)12-8(18)4-7(17)5-10(12)24-16/h2-5,17-20,22H,1H3

Upstream product

• 529-44-2 myricetin 

Relevant academic research and scientific papers

Hypoglycaemic activity of flavonoid isolate from cereus pterogonus lemaire

The flavonoid glycoside isolated from cereus pterogonus Lemaire possesses hypoglycaemic activity. The aglycone is myricetin-5'-Omethyl ether and the sugars are glucose and rhamnose. All these were characterized by UV, 1H NMR, 13C NMR and MS studies.

Flavonoid 3′-O-methyltransferase from rice: cDNA cloning, characterization and functional expression

Plant O-methyltransferases (OMTs) are known to be involved in methylation of plant secondary metabolites, especially phenylpropanoid and flavonoid compounds. An OMT, ROMT-9, was cloned and characterized from rice using a reverse transcriptase polymerase chain reaction (RT-PCR). The blast results for ROMT-9 showed a 73% identity with caffeic acid OMTs from maize and Triticum aestivum. ROMT-9 was expressed in Escherichia coli and its recombinant protein was purified using affinity chromatography. It was then tested for its ability to transfer the methyl group of S-adenosyl-l-methionine to the flavonoid substrates, eriodictyol, luteolin, quercetin, and taxifolin, all of which have a 3′-hydroxyl functional group. The reaction products were analyzed using TLC, HPLC, HPLC/MS, and NMR spectroscopy. The NMR analysis showed that ROMT-9 transferred the methyl group specifically to the 3′-hydroxyl group of quercetin, resulting in the formation of its methoxy derivative. Furthermore, ROMT-9 converted flavonoids containing the 3′-hydroxy functional group such as eriodictyol, luteolin, quercetin and taxifolin into the corresponding methoxy derivatives, suggesting that ROMT-9 is an OMT with strict specificity for the 3′-hydroxy group of flavonoids.