53475-48-2

Upstream product

• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 62-53-3 aniline 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Relevant academic research and scientific papers

2-Anilino-4,6-dimethylpyridine-3-carbonitrile, an intermediate in the synthesis of 5-aminobenzo[b][1,8]naphthyridines

The title compound, C14H13N3, is an intermediate in the synthesis of the corresponding 5-aminobenzo[b][1,8]-naphthyridine. Problems of isomerism occur with this series. According to the crystal structure, conformational fe

Preparation method and application of 5-aminobenzene[b][1,8]naphthyridine compound

The invention belongs to the field of pharmaceutical chemistry, and specifically provides a preparation method and application of a 5-aminobenzene[b][1,8]naphthyridine compound. The preparation methodis a route for synthesis of the 5-aminobenzene [b][1,8] naphthalidine compound by intramolecular cyclization of a molecule of a 4,6-2-disubstituted-2-Naryl-3nitrile compound catalyzed by trifluoro-methanesulfonic acid, more 5-aminobenzene[b][1,8]naphthalidine compounds can be prepared, and the prepared compounds show good antitumor activity in vitro.