5348-27-6Relevant academic research and scientific papers
Evaluation of antibacterial activity of some Schiff bases
Baluja, Shipra,Parikh, Jigna,Chanda, Sumitra,Vaishnani
experimental part, p. 1338 - 1342 (2010/08/05)
From 4-amino phenol, some Schiff bases were synthesized. By IR and NMR spectral data, the structural characterization of these synthesized compounds were done. The antibacterial activity of all these synthesized Schiff bases was studied against B. cereus-ATCC 11778, P. aero-ATCC 27853, E. coli-ATCC 25922, K pneu-NCIM 2719 and 5. aureus-ATCC 25923, by agar ditch method in dimethyl formamide and dimethyl sulfoxide. It is observed that antibacterial activity depends on the molecular structure of Schiff base, solvent used and bacterial strain under consideration. Out of two solvents studied, dimethyl formamide is proved to be best and salicylaldehyde as side chain to 4-amino phenol could be used as lead molecule in drug designing i.e. in inhibiting above bacterial strains.
