53484-49-4Relevant articles and documents
SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00398, (2015/07/16)
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
Fluorinated tropane alkaloids generated by directed biosynthesis in transformed root cultures of Datura stramonium
O'Hagan, David,Robins, Richard J.,Wilson, Marina,Wong, Chi W.,Berry, Marc,Zabetakis, Ioannis
, p. 2117 - 2120 (2007/10/03)
2′-, 3′- and 4′-Fluorophenyl-(RS)-lactic acids were administered to transformed root cultures of Datura stramonium to determine their abilities as substrates for incorporation into the phenyllactoyl and tropoyl ester moieties of the tropane alkaloids, littorine and hyoscyamine respectively. In the event, all of the fluorinated phenyllactates generated the corresponding fluorinated littorine and hyoscyamine analogues. The efficiency of conversion for the isomerisation of the fluorinated littorines (F-lit) to fluorinated hyoscyamines was 3′-F-lit > 4′-F-lit ? 2′-F-lit.
