53510-31-9Relevant academic research and scientific papers
Synthesis of aminoisoquinolines via Rh-catalyzed [4 + 2] annulation of benzamidamides with vinylene carbonate
Huang, Xin,Xu, Yingying,Li, Jianglian,Lai, Ruizhi,Luo, Yi,Wang, Qiantao,Yang, Zhongzhen,Wu, Yong
supporting information, p. 3518 - 3521 (2021/06/12)
A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives. This Rh(III)-catalyzed [4 + 2] annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate. Additionally, the reaction features broad substrate scopes and good yields, only producing carbonate anion as byproduct.
Copper-Catalyzed Intramolecular C-H Amination: A New Entry to Substituted Xanthine Derivatives
Shimizu, Maki,Hayama, Noboru,Kimachi, Tetsutaro,Inamoto, Kiyofumi
, p. 4183 - 4190 (2017/09/12)
Catalytic synthesis of xanthines was achieved in the presence of a copper catalyst. The process involves copper-catalyzed intramolecular C-H amination of benzamidines that possess a uracil moiety and produces variously substituted xanthines generally in good to high yields. This work introduces a new, facile approach to polysubstituted xanthine compounds..
Synthesis of bis(N-acylamidines) from amidines and N-acylbenzotriazoles
Clodt, Juliana Isabel,Hack, Verena Dorothea,Froehlich, Roland,Wuerthwein, Ernst-Ulrich
experimental part, p. 1485 - 1492 (2010/10/20)
Bis(N-acylamidines) 7, linked by a spacer connected to the carboxyl groups, were synthesized in moderate to good yields from bis(N-acylbenzotriazoles) 6 and amidines 2. In contrast, the corresponding bis(carboxylic acid) chlorides were not well suited for
