53518-98-2 Usage
Uses
Used in Pharmaceutical Industry:
N-Benzoyl-d5-glycine is used as a labeled compound for the detection and quantification of hippuric acid in biological samples. This is important for monitoring the metabolism of benzoic acid and its conjugation with glycine in the liver.
Used in Chemical Research:
N-Benzoyl-d5-glycine is used as a research tool in the study of chemical reactions and mechanisms involving benzoic acid and its derivatives. Its labeled nature allows for easier tracking and identification of reaction products.
Used in Analytical Chemistry:
N-Benzoyl-d5-glycine is used as an internal standard or reference compound in analytical techniques such as mass spectrometry and chromatography. Its stable isotopic labeling helps in the accurate quantification of related compounds in complex samples.
Used in Toxicology Studies:
N-Benzoyl-d5-glycine can be used in toxicology studies to investigate the effects of benzoic acid and its metabolites on various biological systems. Its labeled form provides a means to differentiate between endogenous and exogenous sources of hippuric acid in toxicological assessments.
Check Digit Verification of cas no
The CAS Registry Mumber 53518-98-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,5,1 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 53518-98:
(7*5)+(6*3)+(5*5)+(4*1)+(3*8)+(2*9)+(1*8)=132
132 % 10 = 2
So 53518-98-2 is a valid CAS Registry Number.
53518-98-2Relevant academic research and scientific papers
Pierce,Lewandowski,Dills,Morgan,Wessels,Shen,Kalman
, p. 93 - 108 (1999)
1. To examine the bioequivalence of an isotope-labelled tracer to study toxicant disposition, we conducted 33 controlled human exposures to a mixture of 50 ppm 1H8-toluene and 50 ppm 2H8-toluene for 2 h, and measured concentrations in blood and breath, and metabolite levels in urine for 100 h post-exposure. 2. A physiologically based kinetic (PBK) model found that compared with 1H8-toluene, 2H8-toluene had a 6.4 ± 13% (mean ± SD) lower AUC, a 6.5 ± 13% higher systemic clearance (1.46 ± 0.27 versus 1.38 ± 0.25 l/h-kg), a 17 ± 22%, larger terminal volume of distribution (66.4 ± 14 versus 57.2 ± 10 l/kg) and a 9.7 ± 26% longer terminal half-life (38 ± 12 versus 34 ± 10 h) (p 2H8-toluene clearance may have been due to an increased rate of ring oxidation, consistent with the 17% higher observed fraction of 2H5- versus 1H5-cresol metabolites in urine. 4. The larger terminal volume and half-lives for 2H8-toluene suggested a higher adipose tissue/blood partition coefficient. 5. Observed isotope differences were small compared with interindividual differences in 1H8-toluene kinetics from previous studies. 6. The PBK model allowed us to ascribe observed isotope differences in solvent toxicokinetics to underlying physiologic mechanisms.
