53524-88-2

Usage

Uses

Used in Chemical Research:
NAPHTHO[2,1-B]FURAN-2-CARBOHYDRAZIDE is used as a research compound for its unique structure and potential applications in the development of new chemical entities.
Used in Pharmacological Studies:
NAPHTHO[2,1-B]FURAN-2-CARBOHYDRAZIDE is used as a pharmacological agent for its potential therapeutic properties, which are currently under investigation in various research settings.
Used in Drug Development:
NAPHTHO[2,1-B]FURAN-2-CARBOHYDRAZIDE is used as a lead compound in the process of drug discovery, where its chemical properties and interactions with biological targets are being explored for the development of new therapeutic agents.
Used in Material Science:
NAPHTHO[2,1-B]FURAN-2-CARBOHYDRAZIDE is used as a component in the synthesis of advanced materials, where its unique structure may contribute to the creation of novel materials with specific properties.
Note: The exact applications and safety information of NAPHTHO[2,1-B]FURAN-2-CARBOHYDRAZIDE may be proprietary and not publicly available due to its importance in research and potential commercial applications.

InChI:InChI=1/C13H10N2O2/c14-15-13(16)12-7-10-9-4-2-1-3-8(9)5-6-11(10)17-12/h1-7H,14H2,(H,15,16)

Upstream product

• 5656-67-7 acide naphtho<2,1-b>furanne carboxilique 
• 32730-03-3 2-carbetossinafto<2,1-b>furano 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 

Downstream Products

• 496915-68-5 naphtho[2,3-a]furan-2-carboxy-[2'-hydroxyphenyl]carbohydrazone 
• 496915-63-0 naphtho[2,1-b]furan-2-carboxylic acid (4-chloro-benzylidene)-hydrazide 
• 496915-67-4 naphtho[2,1-b]furan-2-carboxylic acid (3-nitro-benzylidene)-hydrazide 
• 496919-77-8 naphtho[2,1-b]furan-2-carboxylic acid (3-chloro-benzylidene)-hydrazide 
• 444009-57-8 naphtho[2,1-b]furan-2-carboxylic acid (3-hydroxy-benzylidene)-hydrazide 
• 1148119-88-3 4-anilino-5-naphtho[2,1-b]furan-2-yl-4H-[1,2,4]-triazole-3-thiol 
• 941670-16-2 C₂₄H₁₆ClN₃O₂ 
• 371135-20-5 STK899704 

Relevant academic research and scientific papers

Rapid and Selective Detection of Cyanide Anion by Enhanced Fluorescent Emission and Colorimetric Color Changes at Micromole Levels in Aqueous Medium

One main source of cyanide (CN?) exposure for mammals is through the plant consumption; thus, the sensitive and selective cyanide detection in plant tissue is a significant and urgent work. Here, a simple sensor N′-(2,4-dihydroxybenzylidene)naphtha[2,1-b]furan-2-carbohydrazide (Q1-3) was designed and synthesized for selective and sensitive dual-channel detection of cyanide in aqueous medium (DMSO/H2O, 1:9, v/v). Acylhydrazone and phenolic hydroxyl groups on Q1-3 are the recognition sites, and naphthofuran group is the signal report group. The intramolecular charge transfer between the benzene group and naphthofuran group was impeded because of the electron-withdrawing groups (hydroxyl) on sensor Q1-3. Interestingly, the sensor Q1-3 exhibited an intramolecular charge transfer absorption band at 400?nm and emission band at 500?nm, respectively, directly realizing an “OFF–ON” response after the deprotonation process induced by cyanide anions in aqueous medium (DMSO/H2O, 1:9, v/v). Notably, this sensor was successfully applied to detect cyanide anions in food samples, which proves a very simple and selective platform for on-site monitoring of cyanide in agriculture samples. In addition, the test strips and silica gel plates based on Q1-3 were also fabricated, which could act as test kits and silica gel plates for convenient and efficient detection of cyanide anions.

NOVEL TUBULIN POLYMERIZATION INHIBITOR AND METHOD FOR SYNTHESIZING SAME

The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60%, or higher, leading to a very high yield, thereby providing an effective synthesis method.

A highly selective PET-based chemosensor for instant detecting of Zn 2+

A simple Zn2+-selective chemosensor system based on acylhydrazone was designed and synthesized, which could detect Zn2+ ions in aqueous solution with high selectivity and sensitivity over a wide pH range by the mechanism of photo-ind

Synthesis of novel nitrogen containing naphtho[2,1-b]furan derivatives and investigation of their anti microbial activities

Ethyl naphtho[2,1-b]furan-2-carboxylate has been prepared from 2-hydroxy-1- naphthaldehyde 1 and ethyl chloroacetate, which on further treatment with hydrazine hydrate gave naphtha[2,1-b]furan-2-carbohydrazide 3. The resulting compound 3 was treated with substituted aldehydes of 2-chloro-3-formylquinolines to give the Schiff base, which on treatment with chloro acetyl chloride gave the title compounds. The structure of the compounds has been confirmed by elemental analysis and spectral studies. The synthesized compounds were screened for their antibacterial and antifungal activities. ARKAT.