53548-18-8

Upstream product

• 98-95-3 nitrobenzene 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 100-65-2 N-Phenylhydroxylamine 

Downstream Products

• 139174-41-7 2-phenyl-3-(2,4-dichlorophenyl)-6-oxo-8,8-dimethyl-1-oxa-2,7-diazaspiro<4,4>-non-2-ene 
• 139174-41-7 2-phenyl-3-(2,4-dichlorophenyl)-6-oxo-8,8-dimethyl-1-oxa-2,7-diazaspiro<4,4>-non-2-ene 
• 1360554-73-9 rac-[(3R,4S,5S)-3-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-2-phenylisoxazolidin-4-yl][(3S,4R,5R)-3-(2,4-di-chlorophenyl)-5-(4-methoxyphenyl)-2-phenylisoxazolidin-4-yl]methanone 
• 1360554-72-8 rac-[(3R,4S,5S)-3-(4-dichlorophenyl)-5-(4-methylphenyl)-2-phenylisoxazolidin-4-yl][(3S,4R,5R)-3-(2,4-dichlorophenyl)-5-(4-methylphenyl)-2-phenylisoxazolidin-4-yl]methanone 
• 1360554-71-7 rac-[(3R,4S,5S)-3-(4-dichlorophenyl)-2,5-diphenylisoxazolidin-4-yl][(3S,4R,5R)-3-(2,4-dichlorophenyl)-2,5-diphenylisoxazolidin-4-yl]methanone 
• 1254524-75-8 N-(1-(2,4-dichlorophenyl)-2-phenylethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 
• 1401091-82-4 N-(2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)ethyl)-N-phenyl-O-(trimethylsilyl)hydroxylamine 

Relevant academic research and scientific papers

An unexpected catalytic synthesis of novel and known bis(pyrazolyl) methanes by the use of α-aryl-N-phenyl nitrones in aqueous media

Reaction of -aryl-N-phenyl nitrones with 3.methyl-1-phenyl-2-pyrazoline-5-one in the presence of a catalytic amount of silica tungstic acid in EtOH/H2O afforded, unexpectedly, high yields of bis(3-hydroxy-1-phenylpyrazolyl)-arylmethanes instead of the two possible 1,3-addition products. This is the first report of the synthesis of bis(3-hydroxy-1-phenylpyrazolyl)-arylmethanes via the reaction of nitrones and a pyrazolin-5-one. A possible mechanism for the process is suggested.

Synthesis of C, N-diaryl nitrones from the reduction of nitroarene with aromatic aldehydes promoted by metallic samarium

A mild and facile reduction of nitroarene with aromatic aldehydes promoted by metallic samarium to C, N-diaryl nitrones in moderate yields has been developed.

1,3-Dipolar cycloaddition reactions of nitrones to prop-1-ene-1,3-sultone

The reaction of prop-1-ene-1,3-sultone (1) with a variety of nitrones 2 afforded novel [3+2] cycloaddition products 3, 4, and 5 in good yield. Excellent regio- and stereoselectivity were achieved in the cycloaddition reaction with phenylnitrones.