53560-31-9

Upstream product

• 20329-98-0 (E)-3,4,5-trimethoxy-cinnamic acid 
• 90-50-6 3,4,5-trimethoxycinnamic acid 
• 20329-96-8 methyl 3,4,5-trimethoxycinnamate 

Downstream Products

• 234123-50-3 5-[(Z)-2-Bromoethenyl]-1,2,3-trimethoxybenzene 
• 312600-72-9 2-(E-2-bromo-1-ethenyl)-3,4,5-trimethoxybenzene 

Relevant academic research and scientific papers

An efficient microwave-promoted route to (Z)-stilbenes from trans-cinnamic acids: Synthesis of combretastatin A-4 and analogues

cis-Stilbenes were synthesized from trans-cinnamic acids, involving ethylenic-bond bromination and a subsequent one-pot microwave-promoted stereoselective debrominative decarboxylation-Suzuki cross-coupling strategy. This sequence represents a useful way to prepare a variety of combretastatin A-4 derivatives.

Kumada-Corriu cross coupling route to the anti-cancer agent combretastatin A-4

A short and efficient synthesis of the anticancer agent combretastatin A-4 was accomplished from inexpensive starting materials using the iron-catalyzed cross-coupling of a Grignard reagent and a bromostilbene as the key step. Copyright Taylor & Francis Group, LLC.