53560-49-9

Upstream product

• 506-78-5 cyanogen iodide 
• 6966-03-6 2-allyl-2,2-diphenylacetic acid 

Downstream Products

• 99097-69-5 5-(4-Methyl-pent-3-enyl)-4,4-diphenyl-dihydro-furan-2-one 
• 1729-20-0 5-methyl-3,3-diphenyldihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Solid-phase organic synthesis of 5-iodomethyl-dihydrofuran-2-ones with recyclable polymer-supported selenium bromide

Reaction of polystyrene-supported selenium bromide with γ,δ-unsaturated acids and subsequent cleavage from the polymer by treatment with methyl iodide efficiently afforded 5-iodomethyl-dihydrofuran-2- ones in excellent yields. The polymeric reagent can be regenerated and reused as an environmentally friendly reagent. Copyright Taylor & Francis Group, LLC.

NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.

Synthesis of β,β-disubstituted γ-butyrolactones by chemo-selective oxidation of 1,4-diols and γ-hydroxy olefins with rucl3/NaIO4

Substituted γ-butyrolactones represent an important group of structural fragments commonly found in natural products, receptor ligands, and drug molecules. Interest in preparing a library of substituted γ-butyrolactones and finding that limited routes to β-substituted lactones exist, led to the development of an efficient approach for the synthesis of β,β-disubstituted γ-butyrolactones. Readily prepared substituted 1,4-diols and γ-hydroxy olefins were treated with the -RuCl3/NaIO4 oxidation system to provide the target β,β-disubstituted γ-butyrolactones in modest to good yields. The reaction goes through a lactol intermediate that was isolated and characterized for selected compounds. The approach supplies an efficient and versatile method for the synthesis of these important heterocyclic structures. Importantly, the present work is the first report that demonstrates the ability of RuCl3/NaIO4 to selectively oxidize primary hydroxyl groups in the presence of secondary alcohols to prepare lactones in good yields.

Regioselective (Diacetoxyiodo)benzene-promoted halocyclization of unfunctionalized olefins

A metal-free method for intramolecular halocyclization of unfunctionalized olefins was detailed. (Diacetoxyiodo)benzene (PIDA) was very effective for haloamidation, haloetherification, and halolactonization of unfunctionalized olefins. In the presence of

NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE

Pharmaceiiticai compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Iodination of organic substrates with halide salts and H2O2 using an organotelluride catalyst.

[figure: see text] Organotelluride 1 is a water-soluble catalyst for the oxidation of iodide with hydrogen peroxide in pH 6 phosphate buffer. In two-phase systems, organic substrates are efficiently iodinated using 0.8 mol % of catalyst. Water-soluble substrates are iodinated without an organic cosolvent.

Unusual iodine catalyzed lactonization of γ-methyl-γ,δ-pentenoic acids: A facile synthesis of γ,γ-dimethyl-γ-butyrolactones

γ,γ-Dimethyl-γ-butyrolactones were exclusively obtained from γ-methyl-γ,δ-pentenoic acids with a catalytic amount of iodine in good yields in methylene chloride.