53577-58-5

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General Description

2-(3-Chlor-4-hydroxyphenyl)essigsaeureamid, also known as 2-(3-Chloro-4-hydroxyphenyl)acetoamide, is a chemical compound that belongs to the class of acetic acid derivatives. It is a white to off-white powder that is insoluble in water but soluble in organic solvents. This chemical has potential pharmaceutical applications, with studies indicating its anti-inflammatory and analgesic properties. It is also used as an intermediate in the synthesis of various pharmaceutical compounds. However, it is important to handle 2-(3-Chlor-4-hydroxyphenyl)essigsaeureamid with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 141805-68-7 N-(3-Chloro-4-hydroxyphenylacetyl)fumarate 

Relevant academic research and scientific papers

The isolation and synthesis of 3-chloro-4-hydroxyphenylacetamide produced by a plant-associated microfungus of the genus Xylaria

Chemical investigations of the fermentation broth from the microfungus Xylaria sp. have afforded the new natural product 3-chloro-4- hydroxyphenylacetamide 1 and the previously reported fungal metabolite 3-chloro-4-hydroxyphenylacetic acid 2. This letter reports the isolation and full spectroscopic characterisation of compounds 1 and 2 by NMR, UV, IR and MS data. The crystal structure and one-pot synthesis of 3-chloro-4- hydroxyphenylacetamide are also reported.

Biologically Active Metabolites of Fungi, I.-Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analogous Open-Chain Imides

The mixed open-chain imide N-(3-chloro-4-hydroxyphenylacetyl)fumarate (1), named coniothyriomycin, was isolated as a metabolite of the fungus Coniothyrium.The natural product 1 and the analoguos imides 13-15 and 22-24 have been synthesized by base-catalyzed condensation of the imidates 12a-f with acid chlorides 6a-c or the mixed anhydride 21.The compounds 1 and 13-15 were shown to posess remarkable fungicidal and herbicidal activities in short-termed tests. Key Words: Fungal metabolites / Imides, open-chain / Fungicidal activity / Coniothriomycin