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7-bromo-8-methoxy-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one is a complex organic compound belonging to the class of benzodiazepines. It features a benzene ring fused to a diazepine ring, with a bromine atom at the 7th position, a methoxy group at the 8th position, and a phenyl group at the 5th position. 7-bromo-8-methoxy-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one is characterized by its unique molecular structure, which contributes to its potential pharmacological properties. It is a derivative of the benzodiazepine core, which is known for its anxiolytic, sedative, and hypnotic effects. The specific substitution pattern in 7-bromo-8-methoxy-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one may alter its pharmacological profile, making it a subject of interest for researchers in the field of medicinal chemistry.

5358-29-2

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5358-29-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5358-29-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,5 and 8 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5358-29:
(6*5)+(5*3)+(4*5)+(3*8)+(2*2)+(1*9)=102
102 % 10 = 2
So 5358-29-2 is a valid CAS Registry Number.

5358-29-2Downstream Products

5358-29-2Relevant academic research and scientific papers

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

Abdelkafi, Hajer,Michau, Aurélien,Pons, Valérie,Ngadjeua, Flora,Clerget, Alexandra,Ait Ouarab, Lilia,Buisson, David-Alexandre,Montoir, David,Caramelle, Lucie,Gillet, Daniel,Barbier, Julien,Cintrat, Jean-Christophe

, p. 8114 - 8133 (2020)

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

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