53585-95-8

Usage

Uses

Used in Flavor and Fragrance Industry:
(E)-6-Hydroxy-4-methyl-4-hexenoic acid methyl ester is used as a key ingredient in the production of flavors and fragrances for its distinctive fruity, pineapple-like aroma. This application takes advantage of the compound's natural scent to enhance the sensory experience of various products.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (E)-6-Hydroxy-4-methyl-4-hexenoic acid methyl ester serves as an essential building block in the synthesis of various organic compounds and pharmaceuticals. Its chemical structure allows for the creation of new drugs with potential therapeutic benefits.
Used in the Food Industry:
(E)-6-Hydroxy-4-methyl-4-hexenoic acid methyl ester may also find potential applications in the food industry as a flavoring agent. Its pleasant aroma can be utilized to improve the taste and overall appeal of different food products, contributing to a more enjoyable dining experience for consumers.

Upstream product

• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 27872-60-2 (E)-1-acetoxy-5-carboxy-3-methylpent-2-ene 
• 92464-72-7 (2E)-6,7-epoxy-3,7-dimethyl-1-triphenylmethoxy-2-octene 
• 1291070-10-4 methyl (E)-6-((tert-butyldimethylsilyl)oxy)-4-methylhex-4-enoate 
• 960060-33-7 1-(tert-butyldimethylsilyloxy)-3-methylbut-3-en-2-ol 
• 114701-65-4 tert-butyldimethyl((3-methylbut-2-en-1-yl)oxy)silane 
• 556-82-1 3-methyl-2-buten-1-ol 
• 89637-71-8 (E)-3-methyl-6-oxohex-2-en-1-yl benzoate 
• 74-88-4 methyl iodide 
• 33431-27-5 6-Trityloxy-4-methylhex-4-ensaeure 
• 37715-33-6 essigsaeure-<(E)-6,7-dihydroxy-3,7-dimethyl-2-octenyl>ester 
• 37715-34-7 1-Trityloxy-6,7-dihydroxy-3,7-dimethyloct-2-en 
• 33431-26-4 6-Trityloxy-4-methylhex-4-enal 

Downstream Products

• 34185-71-2 3-(5-carboxy-3-methyl-(2E)-penten-1-yl)-2-methyl-1,4-naphthoquinone 

Relevant academic research and scientific papers

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)

The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement of the cis-amide with five-membered heterocycles led to the identification of imidazole 17 (MA-0204), a potent, selective PPARδ modulator with good pharmacokinetic properties. MA-0204 was tested in vivo in mice and in vitro in patient-derived muscle myoblasts (from Duchenne Muscular Dystrophy (DMD) patients); 17 altered the expression of PPARδ target genes and improved fatty acid oxidation, which supports the therapeutic hypothesis for the study of MA-0204 in DMD patients.

ANTICOAGULANT COMPOUNDS AND THEIR USE

According to the invention there is provided a compound of formula (I): wherein R1, R2, R3 and n have meanings given in the description, or a pharmaceutically acceptable solvate, salt or prodrug thereof for use as an anticoagulant.

Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers

We have developed a highly efficient asymmetric allylboration of ketimines with nonchiral γ,γ-disubstituted allylboronic acids by using a chiral amino alcohol as the directing group, which is otherwise challenging. The amino alcohol not only serves as a cheap source of nitrogen and chirality, but also dramatically enhances the reactivity. The versatility of this method was demonstrated by its ability to access all four stereoisomers with adjacent quaternary carbon centers. A reaction model was proposed to explain the diastereoselectivity and the rate-accelerating effect.

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).

A convergent synthesis of mycophenolic acid

A new method for the synthesis of Mycophenolic acid using a convergent approach has been developed where the key step is a palladium mediated allyl-aryl tin coupling.