53590-47-9

Basic information

• Product Name: (5-chloro-1H-indol-2-yl)methanol
• Synonyms: (5-chloro-1H-indol-2-yl)methanol;5-chloro-1H-Indole-2-methanol;(5-Chloroindol-2-yl)methanol;1H-Indole-2-methanol, 5-chloro-
• CAS NO: 53590-47-9
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.62
• Mol File: 53590-47-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 115-117 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 393.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.422±0.06 g/cm3(Predicted)
• PKA: 14.68±0.10(Predicted)
• CAS DataBase Reference: (5-chloro-1H-indol-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-chloro-1H-indol-2-yl)methanol(53590-47-9)
• EPA Substance Registry System: (5-chloro-1H-indol-2-yl)methanol(53590-47-9)

Safety Data

• Hazardous Substances Data: 53590-47-9(Hazardous Substances Data)

Usage

General Description

(5-chloro-1H-indol-2-yl)methanol, also known as 5-chloroindole-2-carbinol, is a chemical compound with a molecular formula C9H9ClNO. It is a derivative of indole, a heterocyclic aromatic organic compound. This chemical has been studied for its potential therapeutic applications, including anti-inflammatory and anticancer properties. It has also been researched for its role in drug development and as a building block in organic synthesis. Its unique molecular structure and properties make it a valuable compound for various scientific and industrial applications.

Upstream product

• 4792-67-0 5-chloro-indole-2-carboxylic acid ethyl ester 
• 10517-21-2 5-chloro-1H-Indole-2-carboxylic acid 
• 87802-11-7 methyl 5-chloroindole-2-carboxylate 

Downstream Products

• 950513-62-9 C₁₈H₁₂NOCl 
• 1616101-45-1 6-chloro-1,2,4-triphenyl-9H-carbazole 
• 1427311-39-4 C₂₆H₂₉ClIN₃O₂ 
• 1427311-23-6 10-chloro-N-cyclohexyl-5-oxo-6-propyl-6,7-dihydro-5H-benzo[6,7][1,4]diazepino[1,2-a]indole-7-carboxamide 
• 148473-22-7 5-Chloro-3-phenylsulfanyl-2-phenylsulfanylmethyl-1H-indole 
• 53590-49-1 5-chloro-1H-indole-2-carbaldehyde 
• 148473-21-6 5-Chloro-2-phenylsulfanylmethyl-1H-indole 

Relevant articles and documents

Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C?N Bonds

We report the method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles by means of acid-base switchable cyclization reactions. The reactions involved cleavage of amide C?N bonds, chemoselective N-1 or C-3 acylation, and 1,4-M

NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS

-The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

Highly enantioselective synthesis of functionalized azepino[1,2-a] indoles via NHC-catalyzed [3+4] annulation

The enantioselective [3+4] annulation of 3-formylindol-2-methyl-malonates with 2-bromoenals catalyzed by NHCs is described to afford functionalized azepino[1,2-a]indoles in high yields with excellent enantioselectivities. This method, in which the 3-formyl group in indoles acts as a necessary mediating group, provided cycloaddition products under mild conditions.