53591-80-3

Basic information

• Product Name: 2',4'-difluorobiphenyl-4-acetic acid
• Synonyms: 2',4'-difluorobiphenyl-4-acetic acid
• CAS NO: 53591-80-3
• Molecular Formula: C14H10 F2 O2
• Molecular Weight: 248.22
• Mol File: 53591-80-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 373°Cat760mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.302g/cm³
• CAS DataBase Reference: 2',4'-difluorobiphenyl-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-difluorobiphenyl-4-acetic acid(53591-80-3)
• EPA Substance Registry System: 2',4'-difluorobiphenyl-4-acetic acid(53591-80-3)

Safety Data

• Hazardous Substances Data: 53591-80-3(Hazardous Substances Data)

Usage

General Description

2',4'-difluorobiphenyl-4-acetic acid is a chemical compound with the molecular formula C14H9F2O2. It is an organic compound that is used in pharmaceutical research and development. This chemical is a derivative of biphenyl-4-acetic acid, which is known for its anti-inflammatory and analgesic properties. The addition of fluorine atoms in the 2' and 4' positions of the biphenyl ring enhances the pharmaceutical properties of the compound, making it a promising candidate for the development of new drugs. Its unique structure and properties make it a valuable tool for studying the structure-activity relationships of pharmaceutical compounds.

Relevant articles and documents

Method for synthesizing biphenylcarboxylic acid compound by using Suzuki coupling reaction

The invention provides a method for synthesizing a biphenylcarboxylic acid compound by using the Suzuki coupling reaction. According to the method, brominated aromatic hydrocarbon and arylboronic acidare used as raw materials, and water-soluble fullerene nanopalladium is used as a catalyst; and the equation of the Suzuki coupling reaction is as described in the specification. In the equation, R1and R2 represent substituents at different positions, may be acceptor or donor substituents, and may be monosubstitutents or polysubstitutent; and R1 and R2 may be identical or different groups. The water-soluble fullerene nanopalladium catalyst is cheap, easily available and environmentally friendly, and has high catalytic activity and stable properties. When the catalyst is used for catalysis ofthe Suzuki coupling reaction, conditions are mild, anhydrous anaerobic treatment and high-temperature treatment are not needed, and cost is low. The method can be applied to the industrial synthesisof non-steroidal anti-inflammatory drugs such as diphenylacetic acid and diflunisal.