53592-44-2Relevant academic research and scientific papers
Ultrasound-Assisted Solvent-Free Parallel Synthesis of 3-Arylcoumarins Using N-Acylbenzotriazoles
Wet-Osot, Sirawit,Duangkamol, Chuthamat,Phakhodee, Wong,Pattarawarapan, Mookda
, p. 279 - 282 (2016)
An ultrasound-assisted one-pot acylation/cyclization reaction between N-acylbenzotriazoles and 2-hydroxybenzaldehydes has been developed for the synthesis of substituted 3-arylcoumarins. Using ultrasound not only allows rapid and clean conversion but also simplifies experimental setup and parallel workup leading to rapid generation of 3-arylcoumarin libraries under mild, solvent-free, and chromatography-free conditions.
Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease
Jalili-Baleh, Leili,Nadri, Hamid,Forootanfar, Hamid,Samzadeh-Kermani, Alireza,Kü?ükk?l?n?, Tuba Tüylü,Ayazgok, Beyza,Rahimifard, Mahban,Baeeri, Maryam,Doostmohammadi, Mohsen,Firoozpour, Loghman,Bukhari, Syed Nasir Abbas,Abdollahi, Mohammad,Ganjali, Mohammad Reza,Emami, Saeed,Khoobi, Mehdi,Foroumadi, Alireza
, p. 223 - 234 (2018)
New series of triazole-containing 3-phenylcoumarin–lipoic acid conjugates were designed as multi-functional agents for treatment of Alzheimer's disease. The target compounds 4a-o were synthesized via the azide-alkyne cycloaddition reaction and their biolo
Ph3P/I2-Mediated Synthesis of 3-Aryl-Substituted and 3,4-Disubstituted Coumarins
Phakhodee, Wong,Duangkamol, Chuthamat,Yamano, Dolnapa,Pattarawarapan, Mookda
, p. 825 - 830 (2017/04/06)
Ph3P/I2-Et3N-mediated one-pot two-step esterification-cyclization toward 3-aryl coumarins and 3-aryl-4-methylcoumarins is reported. The reaction of a variety of aryl acetic acids containing steric or reactive group with 2-
Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins
Quezada, Elias,Delogu, Giovanna,Picciau, Carmen,Santana, Lourdes,Podda, Gianni,Borges, Fernanda,Garcia-Morales, Veronica,Vina, Dolores,Orallo, Francisco
experimental part, p. 270 - 279 (2010/05/18)
A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
