535927-60-7

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 158946-92-0 N²,N^2'-(Pyridine-2,6-dicarbonyl)di(S)leucinehydrazide 
• 158946-77-1 N,N'-bis-(1-carboxy-3-methylbutyl)-2,6-bis-(aminocarbonyl)pyridine 
• 158946-82-8 N^α-bis-dipicolinoyl-L-leucine methyl ester 
• 2666-93-5 (S)-Leu-OMe 
• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1416726-91-4 N^α-dinicotinoylbis(L-leucyl-L-phenylalanine) 
• 1416726-95-8 cyclo-(N^α-dinicotinoyl)bis(L-leucyl-L-phenylalaninyl)-L-lysine 
• 1416727-02-0 C₄₃H₅₅N₇O₈ 
• 1416727-07-5 C₄₃H₅₇N₉O₇ 

Relevant academic research and scientific papers

Synthesis of chiral macrocycles: I. Synthesis and study of cyclo (N α-dinicotinoyl)pentapeptide candidates

A series of linear tetrapeptides and macrocyclic pentapeptides has been synthesized starting with N,N-bis(1-carboxy-2-substituted)-3,5-diaminocarbonyl)pyridine and N,N-bis(1-hydrazonyl-2-substituted)-3,5-diaminocarbonyl)pyridine. Structures of newly synth

Synthesis and reactions of new chiral linear and macrocyclic tetraand penta-peptide candidates

A series of linear and macrocyclic pentapeptide derivatives have been prepared via the coupling of pyridine-2,6-dicarboxylic acid (1) or pyridine-2,6-dicarbonyl dichloride (2) with appropriate amino acid methyl esters. The coupling of 1 or 2 with aminoacid methyl esters gave the corresponding pyridine dipeptide methyl esters 3, which were hydrolyzed with sodium hydroxide to the corresponding acids 4. The latter compounds 4 were coupled with other amino acid methyl esters to afford the corresponding tetrapeptide esters 5, which were hydrolyzed with sodium hydroxide to the corresponding acids 6. Cyclization of tetrapeptide acids with L-lysine methyl ester or with aliphatic diamide derivatives afforded the corresponding cyclic pentapeptide methyl ester derivatives 7 and cyclic tetrapeptide diamines 8, respectively. Finally, hydrolysis with 1 N sodium hydroxide or hydrazinolysis with hydrazine hydrate of methyl esters 7 afforded the corresponding acids 9a - e and hydrazides 10a - e, respectively.